Gut Microbiome Alterations Associated with Diabetes in Mexican Americans in South Texas.
Mexican American population
diabetes
gut microbiome
health disparity
metagenome
Journal
mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636
Informations de publication
Date de publication:
28 06 2022
28 06 2022
Historique:
pubmed:
29
4
2022
medline:
29
4
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Mexican Americans have a high prevalence of diabetes and burden of diabetes-related complications, highlighting the need for novel preventive strategies and noninvasive predictors of diabetes risk tailored to this population. Changes in the gut microbiome have the potential to predict diabetes. Here, we aimed to identify alterations in the gut microbiome associated with diabetes in the high-risk population of Mexican Americans in South Texas. Stool samples were collected from 216 subjects from the population-based Cameron County Hispanic Cohort. Among them, 75 had type 2 diabetes. Taxonomic and functional profiling of the stool samples were assessed by 16S and shotgun metagenomic sequencing, and the influence of genetic factors was explored. The gut microbiome of subjects with diabetes was enriched with proinflammatory Proteobacteria members (Enterobacteriaceae, Escherichia
Identifiants
pubmed: 35477306
doi: 10.1128/msystems.00033-22
pmc: PMC9238400
doi:
Substances chimiques
Butyrates
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Pagination
e0003322Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217674
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000371
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003167
Pays : United States
Références
mSystems. 2017 Mar 7;2(2):
pubmed: 28289733
Nucleic Acids Res. 2020 Jul 2;48(W1):W185-W192
pubmed: 32496546
Brain. 2003 Dec;126(Pt 12):2738-49
pubmed: 14506071
Curr Opin Infect Dis. 2018 Oct;31(5):449-454
pubmed: 30048255
Front Microbiol. 2017 Nov 07;8:2114
pubmed: 29163406
mSystems. 2018 May 15;3(3):
pubmed: 29795809
Front Microbiol. 2015 May 18;6:392
pubmed: 26042091
BMC Med. 2012 Oct 10;10:119
pubmed: 23046549
Hum Mutat. 2019 Sep;40(9):1292-1298
pubmed: 31228310
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
Amino Acids. 2018 Jan;50(1):11-27
pubmed: 29094215
Front Genet. 2019 Jan 22;9:637
pubmed: 30723493
Public Health Genomics. 2015;18(1):40-51
pubmed: 25427668
mSystems. 2017 Dec 5;2(6):
pubmed: 29238752
PLoS One. 2011;6(6):e21515
pubmed: 21720553
APMIS. 2019 Oct;127(10):655-659
pubmed: 31344283
Genet Epidemiol. 2015 May;39(4):276-93
pubmed: 25810074
Nat Med. 2018 Oct;24(10):1526-1531
pubmed: 30150717
Gut Microbes. 2014 Jan-Feb;5(1):28-39
pubmed: 24637807
Endocr Metab Immune Disord Drug Targets. 2016;16(2):99-106
pubmed: 27577947
Curr Diab Rep. 2021 Jan 9;21(1):2
pubmed: 33420878
Am J Hum Genet. 2016 Jan 7;98(1):127-48
pubmed: 26748516
Nat Genet. 2016 Oct;48(10):1284-1287
pubmed: 27571263
Sci Rep. 2019 Sep 19;9(1):13574
pubmed: 31537840
Nature. 2015 Dec 10;528(7581):262-266
pubmed: 26633628
Bioinformatics. 2019 Nov 1;35(22):4851-4853
pubmed: 31233103
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Front Microbiol. 2019 Feb 15;10:223
pubmed: 30828323
Clin Gastroenterol Hepatol. 2019 Apr;17(5):968-975.e5
pubmed: 29902644
PLoS One. 2007 Mar 21;2(3):e312
pubmed: 17375198
Microbiome. 2017 Mar 23;5(1):36
pubmed: 28330508
Nat Med. 2018 Oct;24(10):1532-1535
pubmed: 30150716
Microbiome. 2018 Sep 28;6(1):174
pubmed: 30266099
Prev Chronic Dis. 2010 May;7(3):A53
pubmed: 20394692
J Hepatol. 2018 Oct;69(4):896-904
pubmed: 29886156
EBioMedicine. 2020 Jan;51:102590
pubmed: 31901868
Expert Rev Gastroenterol Hepatol. 2019 Jan;13(1):3-15
pubmed: 30791839
Diabetes Care. 2021 Feb;44(2):519-525
pubmed: 33303638
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
J Mol Biol. 2016 Aug 28;428(17):3408-28
pubmed: 27019298
World J Hepatol. 2015 Jun 18;7(11):1586-94
pubmed: 26085918
Microbiome. 2015 Mar 06;3:7
pubmed: 25763184
Annu Rev Genet. 2016 Nov 23;50:67-91
pubmed: 27617971
Carbohydr Polym. 2021 Mar 1;255:117388
pubmed: 33436217
Immunol Rev. 2021 Sep;303(1):83-102
pubmed: 34331314
Genome Biol. 2011 Jun 24;12(6):R60
pubmed: 21702898
JAMA Netw Open. 2021 Jul 1;4(7):e2118811
pubmed: 34323983
Nat Methods. 2018 Nov;15(11):962-968
pubmed: 30377376
Diabetes Metab Res Rev. 2019 Feb;35(2):e3097
pubmed: 30445663
Environ Microbiol. 2020 Sep;22(9):3909-3921
pubmed: 32686173
Blood. 2019 May 16;133(20):2168-2177
pubmed: 30898860
Diabetes. 2019 Jun;68(6):1353-1358
pubmed: 30885989
Nature. 2018 Mar 8;555(7695):210-215
pubmed: 29489753