The role of ATP-binding cassette subfamily A in the etiology of Alzheimer's disease.
ABCA1
ABCA2
ABCA5
ABCA7
ATP-binding cassette transporter
Alzheimer’s disease
Amyloid β
Cholesterol homeostasis
Journal
Molecular neurodegeneration
ISSN: 1750-1326
Titre abrégé: Mol Neurodegener
Pays: England
ID NLM: 101266600
Informations de publication
Date de publication:
27 04 2022
27 04 2022
Historique:
received:
17
11
2021
accepted:
01
04
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
30
4
2022
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline. Despite decades of research effective therapies are lacking, and a large part of the genetic heritability remains unidentified. ABCA7 and ABCA1, members of the ATP-binding cassette subfamily A (ABCA), were identified as AD risk genes in genome-wide association studies. Nevertheless, genetic and/or functional studies propose a link between AD and two other members of the ABCA subclass, i.e., ABCA2 and ABCA5. Changes in expression or dysfunction of these transporters were found to increase amyloid β levels. This might be related to the common role of ABCA transporters in cellular cholesterol homeostasis, for which a prominent role in AD development has been suggested. In this review, we provide a comprehensive overview and discussion on the contribution of the ABCA subfamily to the etiopathogenesis of AD. A better understanding of the function and identification of disease-associated genetic variants in ABCA transporters can contribute to the development of novel therapeutic strategies for AD.
Sections du résumé
BACKGROUND
Alzheimer's disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline. Despite decades of research effective therapies are lacking, and a large part of the genetic heritability remains unidentified. ABCA7 and ABCA1, members of the ATP-binding cassette subfamily A (ABCA), were identified as AD risk genes in genome-wide association studies. Nevertheless, genetic and/or functional studies propose a link between AD and two other members of the ABCA subclass, i.e., ABCA2 and ABCA5.
MAIN BODY
Changes in expression or dysfunction of these transporters were found to increase amyloid β levels. This might be related to the common role of ABCA transporters in cellular cholesterol homeostasis, for which a prominent role in AD development has been suggested. In this review, we provide a comprehensive overview and discussion on the contribution of the ABCA subfamily to the etiopathogenesis of AD.
CONCLUSIONS
A better understanding of the function and identification of disease-associated genetic variants in ABCA transporters can contribute to the development of novel therapeutic strategies for AD.
Identifiants
pubmed: 35477481
doi: 10.1186/s13024-022-00536-w
pii: 10.1186/s13024-022-00536-w
pmc: PMC9044696
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily A
0
ATP-Binding Cassette Transporters
0
Amyloid beta-Peptides
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
31Informations de copyright
© 2022. The Author(s).
Références
Stem Cell Reports. 2022 Jan 11;17(1):110-126
pubmed: 34919811
Atherosclerosis. 2011 Aug;217(2):407-14
pubmed: 21762915
J Lipid Res. 2017 Jul;58(7):1267-1281
pubmed: 28381441
Acta Neuropathol. 2019 Aug;138(2):201-220
pubmed: 30903345
J Alzheimers Dis. 2016 Sep 6;54(2):569-84
pubmed: 27472885
J Parkinsons Dis. 2012;2(1):41-6
pubmed: 23939407
Nat Genet. 2011 May;43(5):436-41
pubmed: 21460841
Nat Genet. 2013 Dec;45(12):1452-8
pubmed: 24162737
Neurol Genet. 2018 Jan 18;4(1):e211
pubmed: 29379882
J Neurochem. 2006 Apr;97(2):345-55
pubmed: 16539677
J Biol Chem. 2010 Oct 29;285(44):34144-54
pubmed: 20739291
J Neurosci. 2016 Mar 30;36(13):3848-59
pubmed: 27030769
Neurol Genet. 2018 Nov 21;4(6):e286
pubmed: 30569016
Nature. 1991 Feb 21;349(6311):704-6
pubmed: 1671712
Cells. 2019 Mar 01;8(3):
pubmed: 30823664
Alzheimers Dement. 2015 Dec;11(12):1430-1438
pubmed: 26079414
J Alzheimers Dis. 2015;43(3):857-69
pubmed: 25125465
Neurobiol Dis. 2005 Feb;18(1):119-25
pubmed: 15649702
J Biol Chem. 2004 Sep 24;279(39):40987-93
pubmed: 15269217
J Neurosci. 2013 Mar 6;33(10):4387-94
pubmed: 23467355
Curr Alzheimer Res. 2010 Nov;7(7):566-77
pubmed: 20704561
J Neurosci. 2012 Sep 19;32(38):13125-36
pubmed: 22993429
J Mol Biol. 2020 Aug 7;432(17):4922-4941
pubmed: 32687853
J Clin Invest. 2000 Nov;106(10):1205-7
pubmed: 11086021
Am J Hum Genet. 2005 May;76(5):794-803
pubmed: 15756637
Nat Genet. 2011 May;43(5):429-35
pubmed: 21460840
Sci Rep. 2017 Jan 16;7:40273
pubmed: 28091533
QJM. 2005 Dec;98(12):845-56
pubmed: 16258026
J Biol Chem. 2006 Nov 24;281(47):36091-101
pubmed: 16984907
J Alzheimers Dis. 2017;56(3):1075-1085
pubmed: 28106559
Annu Rev Genomics Hum Genet. 2000;1:507-37
pubmed: 11701639
J Lipid Res. 2001 Jul;42(7):1007-17
pubmed: 11441126
Mol Brain. 2011 Jan 07;4:3
pubmed: 21214928
FASEB J. 2004 Jul;18(10):1129-31
pubmed: 15155565
FEBS Lett. 2006 Feb 13;580(4):1178-82
pubmed: 16376881
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23790-23796
pubmed: 31690660
J Biol Chem. 1994 Sep 23;269(38):23403-6
pubmed: 8089103
Biochim Biophys Acta. 2011 Dec;1811(12):1152-64
pubmed: 21810484
Chem Rev. 2019 May 8;119(9):5849-5880
pubmed: 30747526
J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):300-5
pubmed: 24163429
J Mol Neurosci. 2017 Apr;61(4):489-497
pubmed: 28124230
Prog Lipid Res. 2011 Oct;50(4):357-71
pubmed: 21741992
Cell. 1998 Jun 12;93(6):951-60
pubmed: 9635425
Neurosci Lett. 2017 May 10;649:124-129
pubmed: 28400126
Biochem Biophys Res Commun. 2003 Nov 14;311(2):313-8
pubmed: 14592415
Nature. 1995 Aug 31;376(6543):775-8
pubmed: 7651536
Biochem Biophys Res Commun. 2000 Jul 5;273(2):532-8
pubmed: 10873640
Bioessays. 2003 Jan;25(1):72-8
pubmed: 12508285
Nat Genet. 2009 Dec;41(12):1308-12
pubmed: 19915575
Hum Mol Genet. 2003 Jan 1;12(1):23-32
pubmed: 12490529
Neuroreport. 2006 Jun 26;17(9):891-6
pubmed: 16738483
Molecules. 2020 Nov 24;25(23):
pubmed: 33255194
PLoS One. 2012;7(9):e45959
pubmed: 23029339
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E1-9
pubmed: 19141679
Int J Mol Sci. 2020 Dec 27;22(1):
pubmed: 33375396
Neurol Genet. 2016 May 17;2(3):e79
pubmed: 27231719
Neurol Genet. 2018 Mar 21;4(2):e224
pubmed: 29577078
Neurobiol Aging. 2021 Oct;106:307.e1-307.e7
pubmed: 34090711
Microsc Res Tech. 2000 Aug 15;50(4):297-304
pubmed: 10936884
Mol Cell Biol. 2007 Jan;27(1):44-53
pubmed: 17060448
Lancet Neurol. 2015 Aug;14(8):814-822
pubmed: 26141617
Cancer Res. 2001 Apr 15;61(8):3339-47
pubmed: 11309290
J Cell Biol. 2006 Aug 14;174(4):547-56
pubmed: 16908670
Br J Pharmacol. 2019 Sep;176(18):3599-3610
pubmed: 30924124
Acta Neuropathol. 2017 Sep;134(3):475-487
pubmed: 28447221
Alzheimers Dement. 2021 Mar;17(3):327-406
pubmed: 33756057
Biochem Biophys Res Commun. 2001 Feb 16;281(1):249-58
pubmed: 11178988
Annu Rev Genomics Hum Genet. 2005;6:123-42
pubmed: 16124856
J Biol Chem. 2005 Feb 11;280(6):4079-88
pubmed: 15557325
Nat Genet. 2015 May;47(5):445-7
pubmed: 25807283
Am J Hum Genet. 2019 Oct 3;105(4):822-835
pubmed: 31585107
Circ Res. 2006 Aug 18;99(4):389-97
pubmed: 16873719
Brain Res. 2009 Jan 16;1249:34-42
pubmed: 18996096
Biochim Biophys Acta. 2006 May;1762(5):510-24
pubmed: 16540294
Mol Cell Biochem. 2011 Nov;357(1-2):397-404
pubmed: 21660464
Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):534-6
pubmed: 16752360
J Biol Chem. 2021 Jan-Jun;296:100166
pubmed: 33478937
Alzheimers Dement. 2021 Feb;17(2):164-174
pubmed: 33336544
J Biol Chem. 2015 Oct 2;290(40):24152-65
pubmed: 26260791
Science. 1995 Aug 18;269(5226):973-7
pubmed: 7638622
Am J Pathol. 1994 Nov;145(5):1030-5
pubmed: 7977635
JAMA. 2013 Apr 10;309(14):1483-92
pubmed: 23571587
Alzheimers Res Ther. 2015 Dec 10;7(1):73
pubmed: 26654793
J Biol Chem. 2003 Aug 15;278(33):31261-8
pubmed: 12761223
Nat Genet. 1999 Aug;22(4):347-51
pubmed: 10431237
J Lipid Res. 2005 Aug;46(8):1703-11
pubmed: 15930518
Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3220-3231
pubmed: 29971439
Exp Gerontol. 2000 Dec;35(9-10):1343-52
pubmed: 11113612
Alzheimers Dement (N Y). 2020 Nov 25;6(1):e12108
pubmed: 33283039
J Comp Neurol. 2002 Sep 30;451(4):334-45
pubmed: 12210128
Nat Genet. 1999 Aug;22(4):336-45
pubmed: 10431236
Alzheimers Dement. 2016 Jun;12(6):733-48
pubmed: 27016693
J Alzheimers Dis. 2010;21(1):193-205
pubmed: 20413849
Arch Neurol. 2011 Dec;68(12):1569-79
pubmed: 22159054
Biochem J. 2000 Jun 1;348 Pt 2:359-65
pubmed: 10816430
J Biol Chem. 2013 Nov 29;288(48):34414-26
pubmed: 24097981
J Biol Chem. 2005 Dec 30;280(52):43236-42
pubmed: 16207708
Curr Opin Lipidol. 2001 Apr;12(2):105-12
pubmed: 11264981
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20
pubmed: 11309494
Hum Mol Genet. 2017 Jul 15;26(14):2690-2700
pubmed: 28444230
J Biol Chem. 2006 Nov 10;281(45):34503-14
pubmed: 16959783
Acta Neuropathol. 2018 Jun;135(6):827-837
pubmed: 29589097
Arch Neurol. 2012 Jan;69(1):59-64
pubmed: 21911656
Ophthalmology. 2012 Jun;119(6):1199-210
pubmed: 22449572
Biochim Biophys Acta. 2002 May 21;1587(1):60-4
pubmed: 12009425
Neurobiol Aging. 2016 Oct;46:235.e1-9
pubmed: 27289440
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9799-804
pubmed: 8790411
Genomics. 1994 May 1;21(1):150-9
pubmed: 8088782
J Biol Chem. 2012 Jan 6;287(2):1100-11
pubmed: 22086926
J Clin Invest. 2008 Feb;118(2):671-82
pubmed: 18202749
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
J Biol Chem. 2005 Dec 30;280(52):43224-35
pubmed: 16207713
J Neurochem. 2000 Mar;74(3):1008-16
pubmed: 10693931
J Biol Chem. 2007 Feb 2;282(5):2851-61
pubmed: 17121837
Pflugers Arch. 2007 Feb;453(5):555-67
pubmed: 16937116
Genet Med. 2019 Aug;21(8):1751-1760
pubmed: 30643219
Mol Cell Biol. 2005 May;25(10):4138-49
pubmed: 15870284
J Alzheimers Dis. 2017;56(1):215-228
pubmed: 27911314
ASN Neuro. 2009 Apr 30;1(2):
pubmed: 19570031
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81
pubmed: 8446617
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Neurology. 2016 Jun 7;86(23):2134-7
pubmed: 27037229
Am J Hum Genet. 1991 Jun;48(6):1034-50
pubmed: 2035524
J Biol Chem. 2004 Jan 2;279(1):604-11
pubmed: 14570867
J Biol Chem. 2007 Jul 6;282(27):19692-9
pubmed: 17488728
N Engl J Med. 2004 Mar 25;350(13):1296-303
pubmed: 15044640
J Biol Chem. 2000 Sep 8;275(36):28240-5
pubmed: 10858438
J Neurosci. 2019 Nov 27;39(48):9611-9622
pubmed: 31641056
Acta Neuropathol. 2012 Sep;124(3):305-23
pubmed: 22618995
Am J Hum Genet. 2000 Aug;67(2):487-91
pubmed: 10880298
J Neurosci. 2010 May 19;30(20):6862-72
pubmed: 20484628
Arch Gen Psychiatry. 2006 Feb;63(2):168-74
pubmed: 16461860
J Lipid Res. 2010 Sep;51(9):2591-9
pubmed: 20495215
PLoS Genet. 2014 May 15;10(5):e1004333
pubmed: 24831815
J Alzheimers Dis. 2016 Oct 4;54(3):1219-1233
pubmed: 27567858
Neurology. 2016 Jun 7;86(23):2126-33
pubmed: 27037232
PLoS One. 2013 Sep 10;8(9):e73129
pubmed: 24039871
J Biol Chem. 2005 Feb 4;280(5):3989-95
pubmed: 15550377
J Mol Biol. 2003 Jan 10;325(2):259-74
pubmed: 12488094
Nat Genet. 1997 Mar;15(3):236-46
pubmed: 9054934
Biochim Biophys Acta. 2004 Jul 5;1683(1-3):89-100
pubmed: 15238223
Sci Transl Med. 2011 Jun 29;3(89):89ra57
pubmed: 21715678
Acta Neuropathol Commun. 2022 Mar 31;10(1):43
pubmed: 35361255
J Lipid Res. 2006 Sep;47(9):1915-27
pubmed: 16788211
J Intern Med. 2006 Dec;260(6):493-508
pubmed: 17116000
Neurobiol Aging. 2009 Nov;30(11):1890-1
pubmed: 18336955
J Comp Neurol. 2003 Jan 13;455(3):353-67
pubmed: 12483687
Front Neurosci. 2021 Feb 17;15:630502
pubmed: 33679311
Am J Hum Genet. 2009 Dec;85(6):833-46
pubmed: 19944402
Med Sci Monit. 2017 Dec 10;23:5851-5861
pubmed: 29224028
J Lipid Res. 2005 Jan;46(1):86-92
pubmed: 15520449
J Alzheimers Dis. 2018;64(4):1195-1211
pubmed: 30010117
Neurobiol Aging. 2017 Nov;59:220.e1-220.e9
pubmed: 28789839