β-Hydroxybutyrate suppresses colorectal cancer.

3-Hydroxybutyric Acid / metabolism Animals Cell Proliferation Cell Transformation, Neoplastic Colorectal Neoplasms / drug therapy Humans Signal Transduction

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2022
Historique:
received: 29 01 2021
accepted: 16 03 2022
pubmed: 29 4 2022
medline: 7 5 2022
entrez: 28 4 2022
Statut: ppublish

Résumé

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for its prevention and therapy are urgently needed

Identifiants

DOI: 10.1038/s41586-022-04649-6 PMID: 35477756 PMC: PMC9448510
pubmed: 35477756
doi: 10.1038/s41586-022-04649-6
pii: 10.1038/s41586-022-04649-6
pmc: PMC9448510
mid: NIHMS1822948
doi:

Substances chimiques

3-Hydroxybutyric Acid TZP1275679

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

160-165

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R35 CA263922
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK050306
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124369
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA168654
Pays : United States
Organisme : NIA NIH HHS
ID : DP2 AG067511
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139783
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA045508
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218133
Pays : United States
Organisme : NIA NIH HHS
ID : DP2 AG067492
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI141393
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069589
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227629
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140018
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA078831
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055400
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK019525
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

Références

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pubmed: 27124452 pmcid: 4944528

Auteurs

Oxana Dmitrieva-Posocco (O)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Andrea C Wong (AC)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-3373-417X

Patrick Lundgren (P)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Aleksandra M Golos (AM)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Hélène C Descamps (HC)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-5591-5839

Lenka Dohnalová (L)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-2761-2547

Zvi Cramer (Z)

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Yuhua Tian (Y)

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Brian Yueh (B)

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Onur Eskiocak (O)

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Gabor Egervari (G)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Yemin Lan (Y)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Jinping Liu (J)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Jiaxin Fan (J)

Department of Biostatistics Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Jihee Kim (J)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Bhoomi Madhu (B)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Kai Markus Schneider (KM)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-0047-3794

Svetlana Khoziainova (S)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Natalia Andreeva (N)

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Qiaohong Wang (Q)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Ning Li (N)

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Emma E Furth (EE)

Department of Pathology, University of Pennsylvania Medical Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Will Bailis (W)

Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0001-9420-6250

Judith R Kelsen (JR)

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Kathryn E Hamilton (KE)

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Klaus H Kaestner (KH)

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-1228-021X

Shelley L Berger (SL)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-5398-4400

Jonathan A Epstein (JA)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Rajan Jain (R)

Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-1979-044X

Mingyao Li (M)

Department of Biostatistics Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-8180-0621

Semir Beyaz (S)

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Christopher J Lengner (CJ)

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-0574-5189

Bryson W Katona (BW)

Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Sergei I Grivennikov (SI)

Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Christoph A Thaiss (CA)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. thaiss@pennmedicine.upenn.edu.
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. thaiss@pennmedicine.upenn.edu.
Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. thaiss@pennmedicine.upenn.edu.
ORCID: 0000-0001-8226-7718

Maayan Levy (M)

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. maayanle@pennmedicine.upenn.edu.
Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. maayanle@pennmedicine.upenn.edu.
ORCID: 0000-0002-7149-9422

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Butyrates › Hydroxy-butyrates › Acide 3-hydroxy-butyrique › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › Eucaryotes › Animaux › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › β-Hydroxybutyrate suppresses colorectal cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › β-Hydroxybutyrate suppresses colorectal cancer.