Peptide hydrogel with self-healing and redox-responsive properties.
Antimicrobial wound dressing
Copper reduction
Hydrogel
Self-healing and redox-responsive properties
Journal
Nano convergence
ISSN: 2196-5404
Titre abrégé: Nano Converg
Pays: England
ID NLM: 101695675
Informations de publication
Date de publication:
27 Apr 2022
27 Apr 2022
Historique:
received:
20
12
2021
accepted:
06
04
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
29
4
2022
Statut:
epublish
Résumé
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.
Identifiants
pubmed: 35478076
doi: 10.1186/s40580-022-00309-7
pii: 10.1186/s40580-022-00309-7
pmc: PMC9046503
doi:
Types de publication
Journal Article
Langues
eng
Pagination
18Subventions
Organisme : NSF ADVANCE
ID : HRD-1008643
Organisme : NIH HHS
ID : P41GM103521
Pays : United States
Organisme : Syracuse University
ID : CUSE
Informations de copyright
© 2022. The Author(s).
Références
J Am Chem Soc. 2013 Sep 11;135(36):13379-86
pubmed: 23984683
Macromol Rapid Commun. 2019 Apr;40(7):e1800837
pubmed: 30672628
Chem Commun (Camb). 2014 Mar 4;50(18):2356-9
pubmed: 24448590
Chempluschem. 2017 Oct;82(10):1282-1289
pubmed: 31957997
Wound Repair Regen. 2010 Mar-Apr;18(2):266-75
pubmed: 20409151
J Mater Chem B. 2015 Feb 7;3(5):899-910
pubmed: 32262181
Burns Trauma. 2018 Dec 29;6:35
pubmed: 30619904
Adv Mater. 2016 Nov;28(41):9060-9093
pubmed: 27488822
Arch Biochem Biophys. 1995 Jan 10;316(1):515-22
pubmed: 7840659
J Wound Care. 2013 Aug;22(8):407-8, 410-12
pubmed: 23924840
Adv Skin Wound Care. 2009 Dec;22(12):567-73
pubmed: 19935135
Angew Chem Int Ed Engl. 2016 Jul 25;55(31):9017-20
pubmed: 27276534
Adv Drug Deliv Rev. 2018 Jan 1;123:33-64
pubmed: 28782570
Chem Soc Rev. 2016 Aug 22;45(17):4797-824
pubmed: 27301699
J Mater Chem B. 2014 May 7;2(17):2467-2472
pubmed: 26413297
Front Chem. 2018 Oct 02;6:449
pubmed: 30333970
Biopolymers. 2013 Nov;100(6):637-44
pubmed: 24122459
Wound Repair Regen. 1994 Oct;2(4):259-69
pubmed: 17147644
Soft Matter. 2019 Feb 20;15(8):1704-1715
pubmed: 30724947
J Am Chem Soc. 2004 Jul 21;126(28):8592-3
pubmed: 15250678
Biomaterials. 2015;53:379-91
pubmed: 25890736
Carbohydr Polym. 2018 Nov 1;199:445-460
pubmed: 30143150
J Am Chem Soc. 2018 Feb 28;140(8):2869-2874
pubmed: 29406709
J Am Chem Soc. 2013 Apr 3;135(13):5008-11
pubmed: 23521132
Angew Chem Int Ed Engl. 2012 Nov 26;51(48):12099-101
pubmed: 23109367
J Am Col Certif Wound Spec. 2009 Oct 06;1(4):109-13
pubmed: 24527129
Biomacromolecules. 2009 Sep 14;10(9):2694-8
pubmed: 19705838
Adv Mater. 2020 Jul;32(27):e1903762
pubmed: 31599045
J Am Chem Soc. 2004 Oct 6;126(39):12282-3
pubmed: 15453758
J Biomater Sci Polym Ed. 2008;19(8):969-88
pubmed: 18644225
Methods Enzymol. 2011;495:195-210
pubmed: 21419923
Colloids Surf B Biointerfaces. 2013 Aug 1;108:352-7
pubmed: 23587765
Biomacromolecules. 2013 Feb 11;14(2):297-301
pubmed: 23347052
J Mater Chem B. 2021 Mar 4;9(8):1919-1940
pubmed: 33475659
Chem Commun (Camb). 2014 May 30;50(42):5551-3
pubmed: 24667982
ACS Macro Lett. 2013 Dec 17;2(12):1095-1099
pubmed: 35606973
J Am Coll Clin Wound Spec. 2013 Sep 22;4(3):63-6
pubmed: 26236638
Curr Med Chem. 2018;25(41):5782-5797
pubmed: 28933299
Chemistry. 2018 Sep 25;24(54):14316-14328
pubmed: 29667727
ACS Appl Mater Interfaces. 2020 Sep 30;12(39):44205-44214
pubmed: 32871067
Soft Matter. 2020 Nov 18;16(44):10046-10064
pubmed: 32724981
Materials (Basel). 2017 Feb 26;10(3):
pubmed: 28772591
J Mater Chem B. 2019 Apr 21;7(15):2534-2548
pubmed: 32255130
Curr Chem Biol. 2014 Aug;8(2):89-102
pubmed: 26361585
Am J Surg. 1994 Jan;167(1A):2S-6S
pubmed: 8109679
J Am Chem Soc. 2008 Dec 3;130(48):16166-7
pubmed: 18998675
Adv Healthc Mater. 2018 Mar;7(5):
pubmed: 29281172
J Am Chem Soc. 2010 Jul 21;132(28):9526-7
pubmed: 20405940
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9816-21
pubmed: 26216960
ACS Appl Mater Interfaces. 2020 Apr 8;12(14):17091-17099
pubmed: 32154701
Tissue Eng Part B Rev. 2020 Jun;26(3):230-248
pubmed: 31928151
Biomaterials. 2003 Nov;24(24):4385-415
pubmed: 12922151
Contraception. 2008 May;77(5):318-27
pubmed: 18402846
Chem Commun (Camb). 2011 Feb 7;47(5):1619-21
pubmed: 21109894