Assisted Reproductive Technology Outcomes in Women With Heart Disease.
assisted reproductive technology
congenital heart disease
in-vitro fertilization
infertility and heart disease
maternal cardiac risk
modified WHO classification
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
12
2021
accepted:
07
03
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
29
4
2022
Statut:
epublish
Résumé
Women with infertility and heart disease (HD) are increasingly seeking assisted reproductive technology (ART). There is only one other study that examines the safety profile of ART in this population. This study aims to evaluate the cardiac, reproductive, and obstetric outcomes of ART in women with HD. We conducted a retrospective case-control study of women with underlying congenital or acquired HD who underwent ART at a single University fertility center from 1/2010-3/2019. Women undergoing Twenty women with HD were included. 15 (75%) had congenital HD, 1 (5%) had valvular disease, 1 (5%) had acquired cardiomyopathy, and 3 (15%) had arrhythmias. 90% were New York Heart Association class I. 55% of HD cases were modified WHO (mWHO) risk classification 1-2, 40% were mWHO 2-3 or 3, 5% were mWHO 4. Cases underwent 25 IVF, 5 OC, and 5 EB cycles and were compared with 79 controls who underwent 174 cycles. No CV complications or deaths occurred amongst cases following ART or pregnancy. There was no difference in risk of ART or obstetric outcomes amongst cases versus controls. For women with HD in this small, low -risk cohort, ART posed few risks that were similar in frequency to healthy controls.
Sections du résumé
Background
UNASSIGNED
Women with infertility and heart disease (HD) are increasingly seeking assisted reproductive technology (ART). There is only one other study that examines the safety profile of ART in this population. This study aims to evaluate the cardiac, reproductive, and obstetric outcomes of ART in women with HD.
Methods
UNASSIGNED
We conducted a retrospective case-control study of women with underlying congenital or acquired HD who underwent ART at a single University fertility center from 1/2010-3/2019. Women undergoing
Results
UNASSIGNED
Twenty women with HD were included. 15 (75%) had congenital HD, 1 (5%) had valvular disease, 1 (5%) had acquired cardiomyopathy, and 3 (15%) had arrhythmias. 90% were New York Heart Association class I. 55% of HD cases were modified WHO (mWHO) risk classification 1-2, 40% were mWHO 2-3 or 3, 5% were mWHO 4. Cases underwent 25 IVF, 5 OC, and 5 EB cycles and were compared with 79 controls who underwent 174 cycles. No CV complications or deaths occurred amongst cases following ART or pregnancy. There was no difference in risk of ART or obstetric outcomes amongst cases versus controls.
Conclusion
UNASSIGNED
For women with HD in this small, low -risk cohort, ART posed few risks that were similar in frequency to healthy controls.
Identifiants
pubmed: 35479266
doi: 10.3389/fcvm.2022.842556
pmc: PMC9035694
doi:
Types de publication
Journal Article
Langues
eng
Pagination
842556Informations de copyright
Copyright © 2022 Quien, Hausvater, Maxwell and Weinberg.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Fertil Steril. 1994 Mar;61(3):411-22
pubmed: 8137959
CMAJ. 2017 Mar 13;189(10):E391-E397
pubmed: 28385819
Eur Heart J. 2010 Sep;31(17):2124-32
pubmed: 20584777
J Am Coll Cardiol. 2013 Oct 29;62(18):1704-1712
pubmed: 23916924
Am Heart J. 2017 May;187:29-36
pubmed: 28454805
J Am Coll Cardiol. 2014 Oct 28;64(17):1862-4
pubmed: 25443711
BMJ Open. 2018 Sep 28;8(9):e022755
pubmed: 30269070
Circulation. 2001 Jul 31;104(5):515-21
pubmed: 11479246
Hum Reprod Update. 2013 Jul-Aug;19(4):419-27
pubmed: 23670222
Cardiol Ther. 2017 Dec;6(2):157-173
pubmed: 28681178
Mo Med. 2017 May-Jun;114(3):156-159
pubmed: 30228571
Fertil Steril. 2002 Nov;78(5):1116-22
pubmed: 12414003
Hum Fertil (Camb). 2004 Jun;7(2):127-33
pubmed: 15223762
Congenit Heart Dis. 2017 May;12(3):242-250
pubmed: 28580608
BMJ. 2013 Jan 15;346:e8632
pubmed: 23321489
PLoS One. 2014 Mar 18;9(3):e91796
pubmed: 24642641
Eur Heart J. 2013 Mar;34(9):657-65
pubmed: 22968232
Fertil Steril. 2018 Jun;109(6):1038-1043.e1
pubmed: 29871795
Eur J Obstet Gynecol Reprod Biol. 2020 May;248:245-251
pubmed: 32276197
Fertil Steril. 2016 Jan;105(1):73-85.e1-6
pubmed: 26453266
Cardiovasc Diagn Ther. 2018 Dec;8(6):705-715
pubmed: 30740318
Eur Heart J. 2018 Sep 7;39(34):3165-3241
pubmed: 30165544
Eur J Prev Cardiol. 2016 Dec;23(18):1953-1961
pubmed: 27798362