Mechanisms and Therapeutic Strategies of Viral Myocarditis Targeting Autophagy.
autophagy
cardiac fibroblasts
cardiomyocytes
coxsackievirus B3
viral myocarditis
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
12
2021
accepted:
23
02
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
29
4
2022
Statut:
epublish
Résumé
Viral myocarditis is caused by infection with viruses or bacteria, including coxsackievirus B3 (CVB3), and is characterized by acute or chronic inflammatory responses in the heart. The mortality associated with severe viral myocarditis is considerable. In some patients, viral myocarditis may develop into dilated cardiomyopathy or heart failure. Autophagy is involved in a wide range of physiological processes, including viral infection and replication. In the present review, we focus on the responses of cardiac tissues, cardiomyocytes, and cardiac fibroblasts to CVB3 infection. Subsequently, the effects of altered autophagy on the development of viral myocarditis are discussed. Finally, this review also examined and assessed the use of several popular autophagy modulating drugs, such as metformin, resveratrol, rapamycin, wortmannin, and 3-methyladenine, as alternative treatment strategies for viral myocarditis.
Identifiants
pubmed: 35479306
doi: 10.3389/fphar.2022.843103
pii: 843103
pmc: PMC9035591
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
843103Informations de copyright
Copyright © 2022 Yu, Zhou, Wang, Yu, Wang, Liu, Wei, Han, Cheng, Wang, Wang and Zhao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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