Bacterial Toxin-Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin-Resistant Staphylococcus aureus (MRSA) Infection.
MRSA
antibiotic delivery
capsosomes
microparticles
vancomycin
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
29
03
2022
received:
06
01
2022
pubmed:
29
4
2022
medline:
23
7
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria-activated single- and dual-antibiotic drug delivery for preventing methicillin-resistant Staphylococcus aureus (MRSA) bacterial infections. The designed system is based on a capsosome structure, which consists of a mesoporous silica microparticle coated in alternating layers of oppositely charged polymers and antibiotic-loaded liposomes. The capsosomes are engineered and shown to release their drug payloads in the presence of MRSA toxins controlled by the Agr quorum sensing system. MRSA-activated single drug delivery of vancomycin and synergistic dual delivery of vancomycin together with an antibacterial peptide successfully kills MRSA in vitro. The capability of capsosomes to selectively deliver their cargo in the presence of bacteria, producing a bactericidal effect to protect the host organism, is confirmed in vivo using a Drosophila melanogaster MRSA infection model. Thus, the capsosomes serve as a versatile multidrug, subcompartmentalized microparticle system for preventing antibiotic-resistant bacterial infections, with potential applications to protect wounds or medical device implants from infections.
Identifiants
pubmed: 35481905
doi: 10.1002/adhm.202200036
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Toxins
0
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200036Subventions
Organisme : Wellcome Trust
ID : 209121/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207467/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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