Long-term effects of preeclampsia on maternal cardiovascular health and postpartum utilization of primary care: an observational claims data study.
Cardiovascular disease
Hypertension
Preeclampsia
Pregnancy
Primary care
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
01
10
2021
accepted:
01
04
2022
pubmed:
29
4
2022
medline:
17
1
2023
entrez:
28
4
2022
Statut:
ppublish
Résumé
Preeclampsia occurs in up to 15% of pregnancies and constitutes a major risk factor for cardiovascular disease. This observational cohort study aimed to examine the association between preeclamptic pregnancies and cardiovascular outcomes as well as primary and specialized care utilization after delivery. Using statutory claims data we identified women with singleton live births between 2010 and 2017. Main outcomes included the occurrence of either hypertension or cardiovascular disease after one or more preeclamptic pregnancies, number of contacts to a general practitioner or cardiologist after delivery and prescribed antihypertensive medication. Data were analyzed using Cox proportional hazard regression models adjusted for maternal age, diabetes, dyslipidemia, and obesity. The study cohort consisted of 181,574 women with 240,698 births. Women who experienced preeclampsia once had an increased risk for cardiovascular (hazard ratio, HR = 1.29) or hypertensive (HR = 4.13) events. In women affected by recurrent preeclampsia, risks were even higher to develop cardiovascular disease (HR = 1.53) or hypertension (HR = 6.01). In the following years after delivery, general practitioners were seen frequently, whereas cardiologists were consulted rarely (0.3 and 2.4%). Women affected by preeclampsia experience an increased risk of developing chronic hypertension and cardiovascular disease, especially those with recurrent preeclampsia. Future medical guidelines should take this potential risk into account.
Identifiants
pubmed: 35482068
doi: 10.1007/s00404-022-06561-w
pii: 10.1007/s00404-022-06561-w
pmc: PMC9836976
doi:
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
275-284Informations de copyright
© 2022. The Author(s).
Références
Microcirculation. 2002 Jul;9(3):147-60
pubmed: 12080413
Eur J Epidemiol. 2015 Jun;30(6):501-8
pubmed: 25784365
Circulation. 2015 Oct 27;132(17):1667-78
pubmed: 26503749
Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):1-7
pubmed: 23746796
BMJ. 2003 Apr 19;326(7394):845
pubmed: 12702615
Chronic Dis Transl Med. 2015 Sep 26;1(4):197-202
pubmed: 29063007
Hypertension. 2011 Oct;58(4):709-15
pubmed: 21844489
Obstet Gynecol. 2021 Nov 1;138(5):777-787
pubmed: 34619718
Obstet Gynecol. 2013 Nov;122(5):1122-1131
pubmed: 24150027
Br Med Bull. 2009;92:7-32
pubmed: 19776034
Paediatr Perinat Epidemiol. 2017 Mar;31(2):89-98
pubmed: 28218407
Maturitas. 2015 Oct;82(2):153-61
pubmed: 26255680
Obstet Gynecol. 2009 Nov;114(5):961-970
pubmed: 20168095
Gynecol Obstet Fertil. 2001 Jul-Aug;29(7-8):518-22
pubmed: 11575148
Pregnancy Hypertens. 2014 Apr;4(2):97-104
pubmed: 26104417
Hypertension. 2009 Jun;53(6):944-51
pubmed: 19433776
BMJ. 2009 Jun 18;338:b2255
pubmed: 19541696
BMC Pregnancy Childbirth. 2013 Dec 21;13:240
pubmed: 24359495
Am J Obstet Gynecol. 2010 Jul;203(1):38.e1-6
pubmed: 20417492
Am J Obstet Gynecol. 2022 Feb;226(2S):S954-S962
pubmed: 33771361
J Womens Health (Larchmt). 2020 May 29;:
pubmed: 32471323
BMJ. 2017 Jul 12;358:j3078
pubmed: 28701333
Front Cardiovasc Med. 2020 Apr 15;7:59
pubmed: 32351977
Heart. 2017 Feb;103(3):235-243
pubmed: 27530133
Circulation. 2014 Aug 19;130(8):703-14
pubmed: 25135127
Can J Cardiol. 2019 Jun;35(6):761-769
pubmed: 31151712
Obstet Gynecol. 2009 Dec;114(6):1307-1314
pubmed: 19935034
BMJ. 2007 Nov 10;335(7627):978
pubmed: 17975256
J Perinatol. 2016 Dec;36(12):1079-1082
pubmed: 27583396
Reprod Health. 2018 May 18;15(1):81
pubmed: 29776432
Heart. 2013 Aug;99(15):1118-21
pubmed: 23749791
Circulation. 2011 Jun 21;123(24):2856-69
pubmed: 21690502
BMC Pregnancy Childbirth. 2013 Mar 09;13:61
pubmed: 23497157
Circ Res. 2019 Mar 29;124(7):1094-1112
pubmed: 30920918
J Clin Invest. 2013 Jul;123(7):2775-7
pubmed: 23934119
Am J Obstet Gynecol. 1996 Nov;175(5):1365-70
pubmed: 8942516
J Am Heart Assoc. 2018 May 13;7(10):
pubmed: 29755034
Ann Intern Med. 2018 Aug 21;169(4):224-232
pubmed: 29971437
Hypertension. 2003 Jul;42(1):39-42
pubmed: 12743016
Obesity (Silver Spring). 2006 Dec;14(12):2294-304
pubmed: 17189558
Eur J Epidemiol. 2013 Jan;28(1):1-19
pubmed: 23397514
Front Cardiovasc Med. 2019 Nov 29;6:178
pubmed: 31850374
Pregnancy Hypertens. 2017 Oct;10:14-17
pubmed: 29153667
Hypertension. 2016 Feb;67(2):251-60
pubmed: 26667417
J Matern Fetal Neonatal Med. 2016;29(13):2067-72
pubmed: 26371379