Where Are We Now and Where Might We Be Headed in Understanding and Managing Brain Metastases in Colorectal Cancer Patients?
Brain metastasis (BM)
Colorectal cancer (CRC)
Liquid biopsies
Metastatic pathways
Novel treatments
Journal
Current treatment options in oncology
ISSN: 1534-6277
Titre abrégé: Curr Treat Options Oncol
Pays: United States
ID NLM: 100900946
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
accepted:
21
03
2022
pubmed:
29
4
2022
medline:
10
6
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Compared to liver and lung metastases, brain metastases (BMs) from colorectal cancer (CRC) are rare and remain poorly investigated despite the anticipated rise in their incidence. CRC patients bearing BM have a dismal prognosis with a median survival of 3-6 months, significantly lower than that of patients with BM from other primary tumors, and of those with metastatic CRC manifesting extracranially. While liver and lung metastases from CRC have more codified treatment strategies, there is no consensus regarding the treatment of BM in CRC, and their management follows the approaches of BM from other solid tumors. Therapeutic strategies are driven by the number and localisation of the lesion, consisting in local treatments such as surgery, stereotactic radiosurgery, or whole-brain radiotherapy. Novel treatment modalities are slowly finding their way into this shy unconsented armatorium including immunotherapy, monoclonal antibodies, tyrosine kinase inhibitors, or a combination of those, among others.This article reviews the pioneering strategies aiming at understanding, diagnosing, and managing this disease, and discusses future directions, challenges, and potential innovations in each of these domains. • With the increasing survival in CRC, brain and other rare/late-onset metastases are rising. • Distal colon/rectal primary location, long-standing progressive lung metastases, and longer survival are risk factors for BM development in CRC. • Late diagnosis and lack of consensus treatment strategies make BM-CRC diagnosis very dismal. • Liquid biopsies using circulating tumor cells might offer excellent opportunities in the early diagnosis of BM-CRC and the search for therapeutic options. • Multi-modality treatment including surgical metastatic resection, postoperative SRS with/without WBRT, and chemotherapy is the best current treatment option. • Recent mid-sized clinical trials, case reports, and preclinical models show the potential of unconventional therapeutic approaches as monoclonal antibodies, targeted therapies, and immunotherapy. Graphical abstract.
Identifiants
pubmed: 35482170
doi: 10.1007/s11864-022-00982-0
pii: 10.1007/s11864-022-00982-0
pmc: PMC9174111
doi:
Substances chimiques
Antibodies, Monoclonal
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-1000Informations de copyright
© 2022. The Author(s).
Références
JAMA Oncol. 2019 Mar 1;5(3):343-350
pubmed: 30476968
Nat Biomed Eng. 2018 Sep;2(9):696-705
pubmed: 30505627
Neuro Oncol. 2017 Oct 19;19(11):1511-1521
pubmed: 28444227
Ann Oncol. 2016 Oct;27(10):1953-8
pubmed: 27502709
Neoplasia. 2020 Sep;22(9):431-440
pubmed: 32652442
Nat Genet. 2015 Mar;47(3):209-16
pubmed: 25665006
Nature. 2007 Dec 6;450(7171):903-7
pubmed: 18026089
Science. 2017 Jul 07;357(6346):55-60
pubmed: 28684519
Cancer. 2007 Feb 15;109(4):751-60
pubmed: 17211866
Mol Pharm. 2018 Nov 5;15(11):5236-5243
pubmed: 30252484
PLoS One. 2016 May 16;11(5):e0155126
pubmed: 27182774
Future Oncol. 2015;11(8):1201-9
pubmed: 25832877
Pharmacol Res. 2018 Mar;129:414-423
pubmed: 29155017
Nat Commun. 2019 Jul 18;10(1):3190
pubmed: 31320627
Clin Chem. 2013 Sep;59(9):1384-92
pubmed: 23695297
Cancer. 2020 Feb 1;126(3):523-530
pubmed: 31658370
N Engl J Med. 2013 Mar 28;368(13):1199-209
pubmed: 23484797
Cancer Discov. 2015 Nov;5(11):1164-1177
pubmed: 26410082
Radiother Oncol. 2015 Nov;117(2):315-21
pubmed: 26347495
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Case Rep Oncol. 2014 Feb 19;7(1):117-21
pubmed: 24707258
Proc Natl Acad Sci U S A. 2018 May 29;115(22):5774-5779
pubmed: 29760052
Oncology. 2009;76(5):369-74
pubmed: 19321946
J Clin Oncol. 2006 Mar 10;24(8):1289-94
pubmed: 16525184
Nature. 2007 Dec 20;450(7173):1235-9
pubmed: 18097410
World J Surg Oncol. 2014 Jun 30;12:197
pubmed: 24980147
World Neurosurg. 2012 Jan;77(1):130-4
pubmed: 22405392
Br J Cancer. 2011 Mar 15;104(6):1020-6
pubmed: 21364579
Mol Aspects Med. 2019 Oct;69:107-122
pubmed: 31189073
Acta Oncol. 2017 May;56(5):639-645
pubmed: 28447565
Sci Transl Med. 2016 Jul 6;8(346):346ra92
pubmed: 27384348
Clin Colorectal Cancer. 2020 Dec;19(4):263-269
pubmed: 33012679
Int J Radiat Oncol Biol Phys. 1997 Mar 1;37(4):745-51
pubmed: 9128946
Cancer. 2002 May 15;94(10):2698-705
pubmed: 12173339
Med Oncol. 2014 Sep;31(9):152
pubmed: 25108599
Cancer Discov. 2018 Feb;8(2):164-173
pubmed: 29196463
J Clin Oncol. 2009 Jul 20;27(21):3503-9
pubmed: 19451444
Clin Cancer Res. 2004 Dec 15;10(24):8152-62
pubmed: 15623589
Nat Rev Genet. 2019 Feb;20(2):71-88
pubmed: 30410101
Neurooncol Adv. 2020 Mar 16;2(1):vdaa034
pubmed: 32793882
Neuro Oncol. 2017 Jan;19(1):i1-i24
pubmed: 28031389
J Neurooncol. 2005 Oct;75(1):5-14
pubmed: 16215811
Cancer. 1996 Aug 15;78(4):711-6
pubmed: 8756361
J Rheumatol. 1977 Summer;4(2):139-43
pubmed: 881690
Pharm Res. 2015 Jan;32(1):37-46
pubmed: 24962512
Curr Oncol. 2012 Oct;19(5):254-8
pubmed: 23144573
Cancer. 2011 Oct 15;117(20):4623-32
pubmed: 21456008
Clin Cancer Res. 2017 Sep 15;23(18):5416-5425
pubmed: 28576867
J Clin Oncol. 2004 Dec 1;22(23):4772-8
pubmed: 15570078
J Exp Clin Cancer Res. 2019 Oct 17;38(1):419
pubmed: 31623643
J Clin Invest. 2010 Jun;120(6):2030-9
pubmed: 20501944
Front Oncol. 2020 Aug 26;10:1443
pubmed: 32983974
Cancer. 1999 Apr 15;85(8):1677-85
pubmed: 10223560
Cancer Cell. 2017 Mar 13;31(3):326-341
pubmed: 28292436
Oncotarget. 2015 Dec 1;6(38):40836-49
pubmed: 26517811
FEBS Lett. 2017 Aug;591(15):2241-2250
pubmed: 28459503
BMC Cancer. 2016 Apr 01;16:260
pubmed: 27037031
Mol Oncol. 2016 Mar;10(3):374-94
pubmed: 26897752
ESMO Open. 2020 Aug;4(Suppl 2):e000813
pubmed: 32817137
J Clin Oncol. 2009 Nov 1;27(31):5255-61
pubmed: 19738122
Curr Oncol Rep. 2012 Feb;14(1):48-54
pubmed: 22012633
Int J Oncol. 2015 Mar;46(3):1361-8
pubmed: 25572133
Cancer. 2015 Apr 15;121(8):1195-203
pubmed: 25491172
Cancer. 2014 Aug 1;120(15):2316-24
pubmed: 24737664
BMC Cancer. 2012 May 16;12:178
pubmed: 22591372
Mol Oncol. 2015 Apr;9(4):850-60
pubmed: 25605225
Sci Transl Med. 2014 Feb 19;6(224):224ra24
pubmed: 24553385
Nat Genet. 2019 Jul;51(7):1113-1122
pubmed: 31209394
Clin Cancer Res. 2020 Apr 15;26(8):1877-1885
pubmed: 31941831
Vox Sang. 1998;74 Suppl 2:269-74
pubmed: 9704456
C R Seances Soc Biol Fil. 1948 Feb;142(3-4):241-3
pubmed: 18875018
Mol Med. 2015 Oct 27;21 Suppl 1:S25-31
pubmed: 26605644
Clin Cancer Res. 2019 May 15;25(10):3046-3053
pubmed: 30808777
Lancet Oncol. 2019 Apr;20(4):518-530
pubmed: 30857956
Ann Surg Oncol. 1996 Sep;3(5):453-63
pubmed: 8876887
Tech Coloproctol. 2017 Nov;21(11):847-852
pubmed: 29124419
Anticancer Drugs. 2007 Jan;18(1):23-8
pubmed: 17159499
Cancer Res. 2013 May 15;73(10):2965-75
pubmed: 23471846
Cancer Biol Ther. 2015;16(12):1726-37
pubmed: 26553611
J Neurooncol. 2016 Jul;128(3):405-15
pubmed: 26945581
Cancers (Basel). 2018 Dec 10;10(12):
pubmed: 30544743
Cancers (Basel). 2021 Jan 19;13(2):
pubmed: 33477814
Cancer Treat Rev. 2018 Jun;67:71-77
pubmed: 29772459
Ann Oncol. 2014 Mar;25(3):651-657
pubmed: 24504447
Int J Cancer. 2018 Nov 15;143(10):2584-2591
pubmed: 30006930
Recent Results Cancer Res. 2012;195:69-76
pubmed: 22527495
Clin Colorectal Cancer. 2009 Mar;8(2):100-5
pubmed: 19423503
J Clin Pathol. 2014 Oct;67(10):848-53
pubmed: 25008452
Gastroenterology. 2010 May;138(5):1714-26
pubmed: 20100481
Future Oncol. 2017 Jan;13(2):135-144
pubmed: 27578453
Dis Colon Rectum. 1996 May;39(5):541-5
pubmed: 8620805
Int J Colorectal Dis. 2014 Feb;29(2):201-8
pubmed: 24158623
Gut. 2016 Apr;65(4):625-34
pubmed: 25654990
World J Gastroenterol. 2004 Nov 15;10(22):3345-8
pubmed: 15484315
Nat Rev Cancer. 2017 Apr;17(4):223-238
pubmed: 28233803
Jpn J Thorac Cardiovasc Surg. 2003 Jul;51(7):289-96
pubmed: 12892459
Ann Surg Oncol. 2012 Jul;19(7):2195-202
pubmed: 22230943
Colorectal Dis. 2012 Jul;14(7):e378-85
pubmed: 22288509
Clin Chem. 2016 Jun;62(6):796-8
pubmed: 27117467
Clin Chem. 2015 Jan;61(1):112-23
pubmed: 25388429
Clin Colorectal Cancer. 2005 Jul;5(2):108-13
pubmed: 16098251
Sci Transl Med. 2016 Jun 29;8(345):345ra89
pubmed: 27358499
Nat Commun. 2019 May 15;10(1):2163
pubmed: 31092822
Lancet Oncol. 2016 Jul;17(7):976-983
pubmed: 27267608
J Exp Clin Cancer Res. 2011 Jan 18;30:10
pubmed: 21244695
Dis Colon Rectum. 1999 Nov;42(11):1467-71
pubmed: 10566536
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16580-5
pubmed: 24065821
Clin Colorectal Cancer. 2014 Dec;13(4):226-31
pubmed: 25442813
Nat Med. 2017 Apr;23(4):517-525
pubmed: 28288110