Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.

Animals Ecosystem Granuloma Lung Macaca fascicularis Mycobacterium tuberculosis Pulmonary Fibrosis / pathology Tuberculosis
Mycobacterium tuberculosis PET-CT immunology intercellular interactions scRNA-seq single-cell RNA sequencing type 1-type 17 type 2 responses

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
10 05 2022
Historique:
received: 12 10 2021
revised: 08 02 2022
accepted: 07 04 2022
pubmed: 29 4 2022
medline: 18 5 2022
entrez: 28 4 2022
Statut: ppublish

Résumé

Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-inflammatory signaling networks involving diverse cell populations. Granulomas that arose later in infection displayed functional characteristics of restrictive granulomas and were more capable of killing Mtb. Our results define the complex multicellular ecosystems underlying (lack of) granuloma resolution and highlight host immune targets that can be leveraged to develop new vaccine and therapeutic strategies for TB.

Identifiants

DOI: 10.1016/j.immuni.2022.04.004 PMID: 35483355 PMC: PMC9122264
pubmed: 35483355
pii: S1074-7613(22)00175-3
doi: 10.1016/j.immuni.2022.04.004
pmc: PMC9122264
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

827-846.e10

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI143160
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI022553
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM087237
Pays : United States
Organisme : Wellcome Trust
ID : 210662/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : P30 AI060354
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI065380
Pays : United States
Organisme : NIAID NIH HHS
ID : U24 AI118672
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.K.S. reports compensation for consulting and/or SAB membership from Merck, Honeycomb Biotechnologies, Cellarity, Repertoire Immune Medicines, Third Rock Ventures, Hovione, Relation Therapeutics, FL82, Empress Therapeutics, Ochre Bio, and Dahlia Biosciences.C.L. is a shareholder and consultant for Honeycomb Biotechnologies. T.K.H. is a shareholder and consultant for nference, inc.

Références

Nucleic Acids Res. 2013 Apr;41(8):4378-91
pubmed: 23444143
PLoS One. 2013;8(1):e55788
pubmed: 23383283
J Vis Exp. 2017 Sep 5;(127):
pubmed: 28930979
Nature. 2015 Jan 29;517(7536):612-5
pubmed: 25470057
J Pathol. 2006 Jan;208(2):261-9
pubmed: 16362982
Infect Immun. 2014 Jun;82(6):2400-4
pubmed: 24664509
Nature. 2018 Aug;560(7720):649-654
pubmed: 30135581
Tuberculosis (Edinb). 2016 Mar;97:8-17
pubmed: 26980490
Infect Immun. 2016 Apr 22;84(5):1301-1311
pubmed: 26883591
Eur Respir J. 2020 Jan 16;55(1):
pubmed: 31601718
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Front Immunol. 2013 Aug 09;4:235
pubmed: 23950757
N Engl J Med. 2012 Sep 6;367(10):931-6
pubmed: 22931261
Sci Transl Med. 2014 Dec 3;6(265):265ra167
pubmed: 25473035
Antimicrob Agents Chemother. 2013 Sep;57(9):4237-4244
pubmed: 23796926
Science. 2015 Jan 23;347(6220):400-6
pubmed: 25477212
Cell. 2019 Aug 22;178(5):1176-1188.e15
pubmed: 31442406
Annu Rev Immunol. 2013;31:475-527
pubmed: 23516984
Nat Rev Genet. 2017 Jun;18(6):345-361
pubmed: 28392571
Immunity. 2008 Jul 18;29(1):44-56
pubmed: 18585065
Cell. 2012 Feb 3;148(3):434-46
pubmed: 22304914
Front Immunol. 2018 Dec 03;9:2832
pubmed: 30559746
Tuberculosis (Edinb). 2016 Dec;101:102-113
pubmed: 27865379
J Clin Invest. 2011 Nov;121(11):4503-15
pubmed: 21965331
PLoS Pathog. 2014 Oct 16;10(10):e1004426
pubmed: 25329476
PLoS Pathog. 2014 Feb 20;10(2):e1003946
pubmed: 24586159
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Mediators Inflamm. 2015;2015:854507
pubmed: 26640327
J Immunol. 2018 Mar 15;200(6):2090-2103
pubmed: 29440351
Nat Commun. 2014 Apr 03;5:3551
pubmed: 24699451
Nat Med. 2014 Jan;20(1):75-9
pubmed: 24336248
Immunity. 2020 Oct 13;53(4):878-894.e7
pubmed: 33053333
Nat Immunol. 2015 Apr;16(4):343-53
pubmed: 25789684
Nat Methods. 2015 May;12(5):453-7
pubmed: 25822800
Genome Biol. 2018 Feb 6;19(1):15
pubmed: 29409532
Front Physiol. 2020 Jun 23;11:714
pubmed: 32655419
Clin Lab. 2007;53(5-6):321-33
pubmed: 17605408
Immunol Rev. 2015 Mar;264(1):288-307
pubmed: 25703567
Nat Commun. 2019 Oct 17;10(1):4706
pubmed: 31624246
J Virol. 2021 Jul 12;95(15):e0053021
pubmed: 33952647
Nat Immunol. 2022 Feb;23(2):318-329
pubmed: 35058616
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7802-7
pubmed: 23630250
J Exp Med. 2016 Feb 8;213(2):251-71
pubmed: 26834156
Nature. 2014 Jul 3;511(7507):99-103
pubmed: 24990750
PLoS Negl Trop Dis. 2015 Jan 08;9(1):e3432
pubmed: 25569149
Cytokine. 2015 Jul;74(1):5-17
pubmed: 25458968
Am J Respir Crit Care Med. 1996 Feb;153(2):799-804
pubmed: 8564135
Int Rev Immunol. 2015;34(4):318-31
pubmed: 25259411
Genome Biol. 2019 Mar 22;20(1):63
pubmed: 30902100
Cell Microbiol. 2015 Aug;17(8):1085-97
pubmed: 25653138
Front Immunol. 2017 Oct 17;8:1290
pubmed: 29089945
Front Immunol. 2018 Mar 01;9:324
pubmed: 29545791
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Front Immunol. 2013 Jan 07;3:411
pubmed: 23308075
Gigascience. 2020 Dec 26;9(12):
pubmed: 33367645
Sci Adv. 2020 Jul 03;6(27):eaaz7809
pubmed: 32923584
Curr Opin Microbiol. 2012 Feb;15(1):63-70
pubmed: 22074861
Nature. 2020 Jan;577(7788):95-102
pubmed: 31894150
Acta Biochim Biophys Sin (Shanghai). 2013 Jul;45(7):593-600
pubmed: 23681234
mBio. 2017 May 9;8(3):
pubmed: 28487426
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32554933
Am J Pathol. 2012 Aug;181(2):508-14
pubmed: 22721647
Sci Rep. 2016 Sep 12;6:33162
pubmed: 27616470
Nat Immunol. 2013 Jan;14(1):52-60
pubmed: 23160153
Cell Host Microbe. 2021 Feb 10;29(2):165-178.e8
pubmed: 33340449
Science. 2010 May 14;328(5980):852-6
pubmed: 20466922
PLoS Pathog. 2015 Jan 22;11(1):e1004603
pubmed: 25611466
Microbiol Spectr. 2017 Jan;5(1):
pubmed: 28155806
J Investig Dermatol Symp Proc. 2007 May;12(1):22-5
pubmed: 17502865
AIDS Res Hum Retroviruses. 2012 Dec;28(12):1693-702
pubmed: 22480184
J Exp Med. 2018 Jul 2;215(7):1823-1838
pubmed: 29773644
PLoS Pathog. 2013 Jan;9(1):e1003130
pubmed: 23358848
J Immunol. 2007 Apr 15;178(8):5217-26
pubmed: 17404305
Vaccines (Basel). 2018 Dec 14;6(4):
pubmed: 30558246
Cell. 2021 Apr 1;184(7):1757-1774.e14
pubmed: 33761328
J Immunol. 2020 Feb 1;204(3):644-659
pubmed: 31862711
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44
pubmed: 27601645
Infect Immun. 2009 Oct;77(10):4631-42
pubmed: 19620341
Nat Med. 2019 Feb;25(2):255-262
pubmed: 30664782
J Immunother Cancer. 2019 Mar 21;7(1):82
pubmed: 30898149
J Exp Med. 2007 Nov 26;204(12):2803-12
pubmed: 18025126
J Virol. 2016 Jul 11;90(15):6699-6708
pubmed: 27170752
Cell Syst. 2019 Apr 24;8(4):329-337.e4
pubmed: 30954475
Infect Immun. 2018 Jan 22;86(2):
pubmed: 28947646
Nat Med. 2011 Sep 18;17(10):1290-7
pubmed: 21926977
Eur J Immunol. 2013 Nov;43(11):2797-809
pubmed: 24258910
J Infect Dis. 2000 Sep;182(3):902-8
pubmed: 10950787
Nat Med. 2018 Jul;24(7):978-985
pubmed: 29942094
Cell. 2018 May 17;173(5):1307
pubmed: 29775597
PLoS Pathog. 2016 May 31;12(5):e1005667
pubmed: 27244558
Sci Rep. 2021 Oct 4;11(1):19634
pubmed: 34608194
Infect Immun. 2005 Jan;73(1):546-51
pubmed: 15618194
J Autoimmun. 2018 Feb;87:69-81
pubmed: 29254845
Nature. 2013 Apr 25;496(7446):461-8
pubmed: 23467089
Clin Infect Dis. 2005 Aug 1;41 Suppl 3:S189-93
pubmed: 15983898
Cell Rep. 2016 Jul 12;16(2):392-404
pubmed: 27346359
J Immunol. 2013 Jul 15;191(2):773-84
pubmed: 23749634
Arthritis Rheum. 2010 Feb;62(2):340-50
pubmed: 20112395
J Immunol. 2013 Jan 1;190(1):270-7
pubmed: 23233724
Cell Rep. 2022 May 17;39(7):110826
pubmed: 35584684
Cell. 2019 Jul 25;178(3):714-730.e22
pubmed: 31348891
J Immunol. 2005 Feb 15;174(4):2021-9
pubmed: 15699131
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1827-32
pubmed: 25624495
Pediatr Res. 2008 Mar;63(3):232-8
pubmed: 18091341
Cell. 2010 Mar 5;140(5):717-30
pubmed: 20211140
J Immunol. 2008 Jan 1;180(1):122-9
pubmed: 18097011
BMC Genomics. 2017 Oct 25;18(1):824
pubmed: 29070035
PLoS Pathog. 2018 Oct 12;14(10):e1007305
pubmed: 30312351
Nat Med. 2016 Oct;22(10):1094-1100
pubmed: 27595324
Nature. 2018 Oct;562(7727):367-372
pubmed: 30283141
Gut. 2008 Dec;57(12):1682-9
pubmed: 18653729
Tuberculosis (Edinb). 2011 Nov;91(6):497-509
pubmed: 21733755
Infect Immun. 2006 Jul;74(7):3790-803
pubmed: 16790751
Nat Immunol. 2007 Jun;8(6):639-46
pubmed: 17486092
J Immunol. 2011 Mar 15;186(6):3527-37
pubmed: 21317393
Nat Immunol. 2007 Apr;8(4):369-77
pubmed: 17351619
Virulence. 2010 Sep-Oct;1(5):423-7
pubmed: 21178483
PLoS Pathog. 2020 Jul 30;16(7):e1008413
pubmed: 32730321
Immunity. 2021 Jan 12;54(1):99-115.e12
pubmed: 33271118
Nat Commun. 2014 May 28;5:3987
pubmed: 24865484
PLoS Pathog. 2020 Sep 10;16(9):e1008840
pubmed: 32913355
Nat Methods. 2017 Apr;14(4):395-398
pubmed: 28192419
Immunity. 2019 May 21;50(5):1317-1334.e10
pubmed: 30979687
Retrovirology. 2016 Aug 24;13(1):59
pubmed: 27553844
Cell Rep. 2016 Dec 13;17(11):2811-2818
pubmed: 27974195
Cancer Immunol Immunother. 2018 Apr;67(4):675-689
pubmed: 29392336
Infect Immun. 2018 Aug 22;86(9):
pubmed: 29891540
Genom Data. 2015 Jul 02;5:297-301
pubmed: 26484272
Front Immunol. 2020 Dec 11;11:603050
pubmed: 33362785
Sci Transl Med. 2021 Jan 13;13(576):
pubmed: 33441427
Microbes Infect. 2006 Apr;8(4):1179-88
pubmed: 16513383
Cold Spring Harb Perspect Med. 2014 Nov 06;5(9):
pubmed: 25377142
mBio. 2016 Apr 05;7(2):e00342-16
pubmed: 27048801
JCI Insight. 2016 Sep 8;1(14):e86017
pubmed: 27699232
Cell. 2006 Sep 22;126(6):1121-33
pubmed: 16990136
Mucosal Immunol. 2019 Nov;12(6):1370-1381
pubmed: 31434990

Auteurs

Hannah P Gideon (HP)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Travis K Hughes (TK)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Constantine N Tzouanas (CN)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Marc H Wadsworth (MH)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.

Ang Andy Tu (AA)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Todd M Gierahn (TM)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Joshua M Peters (JM)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Forrest F Hopkins (FF)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Jun-Rong Wei (JR)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Conner Kummerlowe (C)

Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nicole L Grant (NL)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Kievershen Nargan (K)

Africa Health Research Institute, Durban, South Africa.

Jia Yao Phuah (JY)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

H Jacob Borish (HJ)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Pauline Maiello (P)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Alexander G White (AG)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Caylin G Winchell (CG)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Sarah K Nyquist (SK)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Sharie Keanne C Ganchua (SKC)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Amy Myers (A)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Kush V Patel (KV)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Cassaundra L Ameel (CL)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Catherine T Cochran (CT)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Samira Ibrahim (S)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jaime A Tomko (JA)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Lonnie James Frye (LJ)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Jacob M Rosenberg (JM)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.

Angela Shih (A)

Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.

Michael Chao (M)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Edwin Klein (E)

Division of Laboratory Animal Research, University of Pittsburgh, Pittsburgh PA, USA.

Charles A Scanga (CA)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.

Jose Ordovas-Montanes (J)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Bonnie Berger (B)

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Joshua T Mattila (JT)

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Rajhmun Madansein (R)

Department of Cardiothoracic Surgery, University of KwaZulu Natal, Durban, South Africa.

J Christopher Love (JC)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Philana Ling Lin (PL)

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Alasdair Leslie (A)

Africa Health Research Institute, Durban, South Africa; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Infection and Immunity, University College London, London, UK.

Samuel M Behar (SM)

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.

Bryan Bryson (B)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

JoAnne L Flynn (JL)

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: joanne@pitt.edu.

Sarah M Fortune (SM)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: sfortune@hsph.harvard.edu.

Alex K Shalek (AK)

Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: shalek@mit.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Granulome › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › Appareil respiratoire › Poumon › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Fibrose pulmonaire › Multimodal profiling of lung granulomas in...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Multimodal profiling of lung granulomas in...