Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities.

Animals Arthritis Hematopoietic Stem Cells Immunity, Innate Mice Myelopoiesis Periodontitis
arthritis bone marrow transplantation comorbidities epigenetic rewiring hematopoietic stem and progenitor cells inflammation myelopoiesis periodontitis trained immunity

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
12 05 2022
Historique:
received: 11 08 2021
revised: 22 02 2022
accepted: 30 03 2022
pubmed: 29 4 2022
medline: 18 5 2022
entrez: 28 4 2022
Statut: ppublish

Résumé

Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-arthritis axis. Experimental-periodontitis-related systemic inflammation in mice induced epigenetic rewiring of HSPC and led to sustained enhancement of production of myeloid cells with increased inflammatory preparedness. The periodontitis-induced trained phenotype was transmissible by BM transplantation to naive recipients, which exhibited increased inflammatory responsiveness and disease severity when subjected to inflammatory arthritis. IL-1 signaling in HSPC was essential for their maladaptive training by periodontitis. Therefore, maladaptive innate immune training of myelopoiesis underlies inflammatory comorbidities and may be pharmacologically targeted to treat them via a holistic approach.

Identifiants

DOI: 10.1016/j.cell.2022.03.043 PMID: 35483374 PMC: PMC9106933
pubmed: 35483374
pii: S0092-8674(22)00393-2
doi: 10.1016/j.cell.2022.03.043
pmc: PMC9106933
mid: NIHMS1794730
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1709-1727.e18

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE028561
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE029436
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE031206
Pays : United States
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests M.G.N. is the scientific founder and member of the Scientific Advisory Board of Trained Therapeutics and Discovery (TTxD). M.G.N. has two patents: US18/61935 (Targeted nanoimmunotherapy to increase trained immunity) and US18/61939 (Targeted nanoimmunotherapy for inhibition of trained immunity). The other authors declare no competing interests.

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Auteurs

Xiaofei Li (X)

Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Hui Wang (H)

Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Xiang Yu (X)

Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Gundappa Saha (G)

Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Lydia Kalafati (L)

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Charalampos Ioannidis (C)

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Ioannis Mitroulis (I)

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany; First Department of Internal Medicine and Department of Haematology, Democritus University of Thrace, 681 00 Alexandroupolis, Greece.

Mihai G Netea (MG)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525 XZ, the Netherlands; Department of Immunology and Metabolism, Life and Medical Science Institute, University of Bonn, 53115 Bonn, Germany.

Triantafyllos Chavakis (T)

Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address: triantafyllos.chavakis@uniklinikum-dresden.de.

George Hajishengallis (G)

Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: geoh@upenn.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Maladaptive innate immune training of...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Arthrite › Maladaptive innate immune training of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Maladaptive innate immune training of...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Maladaptive innate immune training of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Maladaptive innate immune training of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Leucopoïèse › Myélopoïèse › Maladaptive innate immune training of...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies parodontales › Parodontite › Maladaptive innate immune training of...