Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2

Animals Autism Spectrum Disorder / genetics Autistic Disorder / genetics Cerebral Cortex Membrane Proteins / genetics Mice Nerve Tissue Proteins / genetics Somatosensory Cortex Vibrissae
Autism Connectivity Gene expression Somatosensory

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
07 2022
Historique:
received: 10 03 2022
revised: 16 04 2022
accepted: 21 04 2022
pubmed: 29 4 2022
medline: 20 5 2022
entrez: 28 4 2022
Statut: ppublish

Résumé

Sensory abnormalities are a common feature in autism spectrum disorders (ASDs). Tactile responsiveness is altered in autistic individuals, with hypo-responsiveness being associated with the severity of ASD core symptoms. Similarly, sensory abnormalities have been described in mice lacking ASD-associated genes. Loss-of-function mutations in CNTNAP2 result in cortical dysplasia-focal epilepsy syndrome (CDFE) and autism. Likewise, Cntnap2

Identifiants

DOI: 10.1016/j.nbd.2022.105742 PMID: 35483565
pubmed: 35483565
pii: S0969-9961(22)00134-6
doi: 10.1016/j.nbd.2022.105742
pii:
doi:

Substances chimiques

CNTNAP2 protein, mouse 0
Membrane Proteins 0
Nerve Tissue Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

105742

Subventions

Organisme : NIMH NIH HHS
ID : R21 MH116473
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Luigi Balasco (L)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy.

Marco Pagani (M)

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy.

Luca Pangrazzi (L)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy.

Gabriele Chelini (G)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy.

Francesca Viscido (F)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy.

Alessandra Georgette Ciancone Chama (AGC)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy.

Alberto Galbusera (A)

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy.

Giovanni Provenzano (G)

Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy.

Alessandro Gozzi (A)

Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Corso Bettini 31, 38068 Rovereto, Italy.

Yuri Bozzi (Y)

Center for Mind/Brain Sciences - CIMeC, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, TN, Italy; CNR Neuroscience Institute, via Moruzzi 1, 56124 Pisa, Italy. Electronic address: yuri.bozzi@unitn.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex somatosensoriel › Somatosensory cortex hyperconnectivity and...
questionsmedicales.fr › Structures anatomiques de l'animal › Vibrisses › Somatosensory cortex hyperconnectivity and...