Loss of microglial EED impairs synapse density, learning, and memory.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
13
09
2021
accepted:
12
04
2022
revised:
07
04
2022
pubmed:
29
4
2022
medline:
22
6
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
The embryonic ectoderm development (EED) is a core component of the polycomb-repressive complex 2 (PRC2) whose mutations are linked to neurodevelopmental abnormalities, intellectual disability, and neurodegeneration. Although EED has been extensively studied in neural stem cells and oligodendrocytes, its role in microglia is incompletely understood. Here, we show that microglial EED is essential for synaptic pruning during the postnatal stage of brain development. The absence of microglial EED at early postnatal stages resulted in reduced spines and impaired synapse density in the hippocampus at adulthood, accompanied by upregulated expression of phagocytosis-related genes in microglia. As a result, deletion of microglial Eed impaired hippocampus-dependent learning and memory in mice. These results suggest that microglial EED is critical for normal synaptic and cognitive functions during postnatal development.
Identifiants
pubmed: 35484239
doi: 10.1038/s41380-022-01576-w
pii: 10.1038/s41380-022-01576-w
doi:
Substances chimiques
Eed protein, mouse
0
Polycomb Repressive Complex 2
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2999-3009Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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