Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
28 Apr 2022
28 Apr 2022
Historique:
received:
08
09
2021
accepted:
06
04
2022
revised:
27
03
2022
entrez:
28
4
2022
pubmed:
29
4
2022
medline:
29
4
2022
Statut:
aheadofprint
Résumé
Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline. The mechanisms underlying the genotype and apoE level risks are uncertain. Recent fluid and imaging biomarker studies have revealed an unexpected link between apoE and brain iron, which also forecasts disease progression, possibly through ferroptosis, an iron-dependent regulated cell death pathway. Here, we report that apoE is a potent inhibitor of ferroptosis (EC
Identifiants
pubmed: 35484240
doi: 10.1038/s41380-022-01568-w
pii: 10.1038/s41380-022-01568-w
pmc: PMC9757994
mid: NIHMS1851727
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054057
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054057
Pays : United States
Organisme : Alzheimer's Association
ID : AARFD-16-442821
Pays : United States
Informations de copyright
© 2022. The Author(s).
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