The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers.
anticancer
artemisinin
dimers
hybrid molecules
metal complexes
structure-activity relationship
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
28
03
2022
received:
15
02
2022
accepted:
31
03
2022
pubmed:
29
4
2022
medline:
3
8
2022
entrez:
28
4
2022
Statut:
ppublish
Résumé
Cancer, the most significant cause of morbidity and mortality, has already posed a heavy burden on health care systems globally. In recent years, cancer treatment has made a significant breakthrough, but cancer cells inevitably acquire resistance, and the efficacy of the treatment is greatly reduced as the tumor progresses. To overcome the above issues, novel chemotherapeutics are needed urgently. Artemisinin and its derivatives-sesquiterpene lactone compounds possessing a unique peroxy bridge moiety-exhibit excellent safety and tolerability profiles. Mechanistically, artemisinin derivatives can promote cancer cell apoptosis, induce cell cycle arrest and autophagy, and inhibit cancer cell invasion and migration. Accordingly, artemisinin derivatives demonstrate promising anticancer efficacy both in vitro and in vivo, and even in clinical Phase I/II trials. The purpose of the present review article is to provide an emphasis on the current scenario (January 2017-January 2022) of artemisinin derivatives with potential anticancer activity, inclusive of artemisinin metal complexes, hybrids, and dimers. The structure-activity relationships and mechanisms of action are also discussed to facilitate the further rational design of more effective candidates.
Identifiants
pubmed: 35484335
doi: 10.1002/ardp.202200086
doi:
Substances chimiques
Antineoplastic Agents
0
Artemisinins
0
Coordination Complexes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200086Informations de copyright
© 2022 Deutsche Pharmazeutische Gesellschaft.
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