Driving CAR T Cells against Solid Tumors.

Humans Immunotherapy, Adoptive Neoplasms / therapy Receptors, Antigen, T-Cell / genetics Receptors, Chimeric Antigen T-Lymphocytes Tumor Microenvironment

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
06 07 2022
Historique:
pubmed: 30 4 2022
medline: 8 7 2022
entrez: 29 4 2022
Statut: ppublish

Résumé

During the American Association for Cancer Research Annual Meeting 2022, researchers discussed ways to improve chimeric antigen receptor T-cell therapy's efficacy in solid tumors. These included sussing out differences between solid and blood cancers in their susceptibility to CAR T cells' cytotoxicity, taking a modular approach to engineering next-generation agents, and building in breaks for exhaustion-prone CAR T cells to restore their function.

Identifiants

DOI: 10.1158/2159-8290.CD-ND2022-0006 PMID: 35485880
pubmed: 35485880
pii: 694819
doi: 10.1158/2159-8290.CD-ND2022-0006
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Receptors, Chimeric Antigen 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

OF4

Informations de copyright

©2022 American Association for Cancer Research.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Tumeurs › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs chimériques pour l'antigène › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Driving CAR T Cells against Solid Tumors.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Driving CAR T Cells against Solid Tumors.