[Netrin-1, a novel antitumoral target].
La nétrine-1, une nouvelle cible antitumorale.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
entrez:
29
4
2022
pubmed:
30
4
2022
medline:
4
5
2022
Statut:
ppublish
Résumé
Netrin-1, a secreted molecule that was first described for its role in guidance during embryogenesis, was then brought to light for its overexpression in a large number of aggressive cancers. Netrin-1 is a ligand of "dependence receptors". In adults, the interaction between Netrine-1 and these receptors triggers the survival, proliferation, and migration of different cell types. This will confer better survival properties to tumor cells, making them more prone to form aggressive tumors. A recently developed novel therapy aims at inhibiting the binding of Netrin-1 to these receptors in order to trigger cell death by apoptosis. This article presents a review of the functional characteristics of the Netrin-1 molecule, and the potential effects of a novel targeted therapy against Netrin-1 that could lead to very promising results in combination with conventional anti-cancer treatments. La nétrine-1, une nouvelle cible antitumorale. La nétrine-1, une molécule sécrétée mise en évidence pour son rôle de guidage au cours de l’embryogenèse, a été également décrite pour être surexprimée dans de nombreux cancers agressifs. Elle est le ligand de récepteurs dits « à dépendance », à l’origine, chez l’adulte, de la survie, de la prolifération et de la migration de différents types cellulaires, ce qui confère aux cellules cancéreuses des propriétés avantageuses leur permettant de se développer sous forme de tumeurs agressives. Une stratégie thérapeutique consiste à inhiber l’interaction de la nétrine-1 avec son récepteur, ce qui déclenche la mort des cellules par apoptose. Cet article présente une revue des caractéristiques fonctionnelles de cette molécule et les effets potentiels d’une nouvelle thérapie ciblée sur la nétrine-1, dont la combinaison avec les traitements conventionnels pourrait être des plus prometteurs.
Autres résumés
Type: Publisher
(fre)
La nétrine-1, une nouvelle cible antitumorale.
Identifiants
pubmed: 35485895
doi: 10.1051/medsci/2022038
pii: msc200476
doi:
Substances chimiques
NTN1 protein, human
0
Netrin Receptors
0
Receptors, Cell Surface
0
Tumor Suppressor Proteins
0
Netrin-1
158651-98-0
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
351-358Informations de copyright
© 2022 médecine/sciences – Inserm.
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