Impact of Nuclear Envelope Stress on Physiological and Pathological Processes in Central Nervous System.
Neurodegenerative diseases
Nuclear envelope stress
Radial migration
Synapse maturation
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
30
11
2021
accepted:
12
04
2022
revised:
07
04
2022
pubmed:
30
4
2022
medline:
14
9
2022
entrez:
29
4
2022
Statut:
ppublish
Résumé
The nuclear envelope (NE) separates genomic DNA from the cytoplasm and provides the molecular platforms for nucleocytoplasmic transport, higher-order chromatin organization, and physical links between the nucleus and cytoskeleton. Recent studies have shown that the NE is often damaged by various stresses termed "NE stress", leading to critical cellular dysfunction. Accumulating evidence has revealed the crucial roles of NE stress in the pathology of a broad spectrum of diseases. In the central nervous system (CNS), NE dysfunction impairs neural development and is associated with several neurological disorders, such as Alzheimer's disease and autosomal dominant leukodystrophy. In this review, the structure and functions of the NE are summarized, and the concepts of NE stress and NE stress responses are introduced. Additionally, the significant roles of the NE in the development of CNS and the mechanistic connections between NE stress and neurological disorders are described.
Identifiants
pubmed: 35486254
doi: 10.1007/s11064-022-03608-x
pii: 10.1007/s11064-022-03608-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2478-2487Subventions
Organisme : Grants-in-Aid for Scientific Research
ID : JP17H06416
Organisme : Grants-in-Aid for Scientific Research
ID : JP20K21578
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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