Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis.
Alzheimer’s disease
C-reactive protein
Interleukin-6
Tumor necrosis factor-α
Vascular contributions to cognitive impairment and dementia
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
06
09
2021
accepted:
23
03
2022
pubmed:
30
4
2022
medline:
24
6
2022
entrez:
29
4
2022
Statut:
ppublish
Résumé
Vascular contribution to cognitive impairment and dementia (VCID) is a clinical label encompassing a wide range of cognitive disorders progressing from mild to major vascular cognitive impairment (VCI), which is also defined as vascular dementia (VaD). VaD diagnosis is mainly based on clinical and imaging findings. Earlier biomarkers are needed to identify subjects at risk to develop mild VCI and VaD. In the present meta-analysis, we comprehensively evaluated the role of inflammatory biomarkers in differential diagnosis between VaD and Alzheimer's disease (AD), and assessed their prognostic value on predicting VaD incidence. We collected literature until January 31, 2021, assessing three inflammatory markers [interleukin(IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α] from blood or cerebrospinal fluid (CSF) samples. Thirteen cross-sectional and seven prospective studies were included. Blood IL-6 levels were cross-sectionally significantly higher in people with VaD compared to AD patients (SMD: 0.40, 95% CI: 0.18 to 0.62) with low heterogeneity (I
Identifiants
pubmed: 35486344
doi: 10.1007/s11357-022-00556-w
pii: 10.1007/s11357-022-00556-w
pmc: PMC9213626
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1373-1392Informations de copyright
© 2022. The Author(s).
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