Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara.
Anti-inflammation
Eudesmane sesquiterpenoid
NO production inhibition
Quinic acid derivative
Tussilago farfara
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
21
11
2021
entrez:
29
4
2022
pubmed:
30
4
2022
medline:
4
5
2022
Statut:
ppublish
Résumé
Chemical fractionation of the n-BuOH partition, which was generated from the EtOH extract of the flower buds of Tussilago farfara, afforded a series of polar constituents including four new sesquiterpenoids (1-4), one new sesquiterpenoid glucoside (5) and one known analogue (6) of the eudesmane type, as well as five known quinic acid derivatives (7-11). Structures of the new compounds were unambiguously characterized by detailed spectroscopic analyses, with their absolute configurations being established by X-ray crystallography, electronic circular dichroism (ECD) calculation and induced ECD experiments. The inhibitory effect of all the isolates against LPS-induced NO production in murine RAW264.7 macrophages was evaluated, with isochlorogenic acid A (7) showing significant inhibitory activity.
Identifiants
pubmed: 35487600
pii: S1875-5364(21)60120-6
doi: 10.1016/S1875-5364(21)60120-6
pii:
doi:
Substances chimiques
Glucosides
0
Sesquiterpenes
0
Sesquiterpenes, Eudesmane
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-308Informations de copyright
Copyright © 2022 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.