Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet.
Animals
Antioxidants
/ metabolism
Diet, High-Fat
/ adverse effects
Hibiscus
/ metabolism
Inflammation
/ drug therapy
Insulin Resistance
Lipid Metabolism
Lipids
Male
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2
/ metabolism
Non-alcoholic Fatty Liver Disease
/ drug therapy
Plant Extracts
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 04 2022
29 04 2022
Historique:
received:
28
10
2021
accepted:
18
04
2022
entrez:
29
4
2022
pubmed:
30
4
2022
medline:
4
5
2022
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) has become a major world-wide health problem and is characterized by lipid accumulation in the liver induced by high fat diet (HFD) consumption. It is usually associated with inflammation, oxidative stress, and insulin resistance. Roselle extract (Hibiscus sabdariffa) is an herb which is used in traditional medicine. However, further study is necessary to represent the mechanism of NAFLD and find new preventive strategies. This study aims to investigate the protective effects of roselle extract on NAFLD rat models. Male Sprague-Dawley rats (n = 35) were divided into 5 groups, control, HFD, HFD + Simvastatin (HFD + SIM), HFD + 250 mg/kg BW, and HFD + 500 mg/kg BW of roselle extract (HFD + R250 and HFD + R500, respectively). The results showed that roselle extract reduced hepatic lipid contents, de novo lipogenesis enzymes, microsomal triglyceride transfer protein, inflammatory cytokines, malondialdehyde, and increased antioxidant properties, transporter related with lipoprotein uptake, and insulin signal proteins. Comparing to SIM, the HFD + R500 group exhibited the greater benefit in terms of anti-hepatic steatosis, antioxidant properties, and an ability to improve insulin resistance. This study demonstrates that roselle extract improved antioxidant properties and attenuated hepatic steatosis, liver inflammation, oxidative stress, and insulin resistance in HFD-induced NAFLD in rats, which could be used for NAFLD prevention.
Identifiants
pubmed: 35487948
doi: 10.1038/s41598-022-11027-9
pii: 10.1038/s41598-022-11027-9
pmc: PMC9054782
doi:
Substances chimiques
Antioxidants
0
Lipids
0
NF-E2-Related Factor 2
0
Plant Extracts
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7022Informations de copyright
© 2022. The Author(s).
Références
Biomed Res Int. 2019 Apr 7;2019:8748253
pubmed: 31080832
Int J Prev Med. 2013 Jun;4(6):624-30
pubmed: 23930179
J Nutr Sci Vitaminol (Tokyo). 2019;65(4):349-356
pubmed: 31474685
Evid Based Complement Alternat Med. 2012;2012:620384
pubmed: 23258993
Am J Cardiovasc Drugs. 2008;8(6):373-418
pubmed: 19159124
Indian J Exp Biol. 2009 Apr;47(4):276-82
pubmed: 19382724
Arch Toxicol. 2020 Oct;94(10):3381-3407
pubmed: 32852569
Biomed Res Int. 2015;2015:837452
pubmed: 26078966
J Agric Food Chem. 2010 Jan 27;58(2):850-9
pubmed: 20017484
Phytomedicine. 2010 Jun;17(7):500-5
pubmed: 19962289
Eur J Nutr. 2018 Apr;57(3):965-979
pubmed: 28161724
Am J Chin Med. 2019;47(6):1253-1270
pubmed: 31488034
Liver Int. 2017 Feb;37(2):173-178
pubmed: 27860156
Anal Biochem. 2018 Feb 1;542:29-33
pubmed: 29175424
Sci Rep. 2019 Feb 28;9(1):2999
pubmed: 30816148
Int J Mol Sci. 2016 May 20;17(5):
pubmed: 27213358
Biomed Pharmacother. 2021 Jun;138:111438
pubmed: 33721756
Food Funct. 2021 May 11;12(9):3855-3871
pubmed: 33704297
World J Gastroenterol. 2017 Sep 28;23(36):6549-6570
pubmed: 29085205
Oxid Med Cell Longev. 2020 Oct 19;2020:1617805
pubmed: 33149804
Oxid Med Cell Longev. 2018 Jul 2;2018:4051232
pubmed: 30057677
Exp Ther Med. 2018 Oct;16(4):3345-3352
pubmed: 30250521
Biol Pharm Bull. 2005 Mar;28(3):481-4
pubmed: 15744073
Metab Brain Dis. 2019 Aug;34(4):1091-1102
pubmed: 31119507
Drugs. 1995 Aug;50(2):334-63
pubmed: 8521762
Clin Exp Pharmacol Physiol. 2011 May;38(5):338-44
pubmed: 21401695
Cell Metab. 2017 Jun 6;25(6):1216-1230
pubmed: 28591630
J Biol Chem. 1994 Nov 18;269(46):29138-45
pubmed: 7961879
Pharmacognosy Res. 2014 Oct-Dec;7(4):355-62
pubmed: 26692750
ISRN Gastroenterol. 2011;2011:976019
pubmed: 21991538
Int J Mol Sci. 2014 Nov 21;15(11):21505-37
pubmed: 25421245
Pharmacol Res. 2021 May;167:105562
pubmed: 33737240
Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4328-4336
pubmed: 27831639
Food Nutr Res. 2015 Oct 15;59:29018
pubmed: 26475512
BMC Complement Altern Med. 2010 Jun 17;10:27
pubmed: 20553629
Dig Dis. 2010;28(1):155-61
pubmed: 20460905
Biochim Biophys Acta. 2011 Nov;1812(11):1557-66
pubmed: 21840395
Food Funct. 2018 Sep 19;9(9):4906-4915
pubmed: 30178808
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
PLoS One. 2020 Jul 1;15(7):e0235338
pubmed: 32609782
World J Gastroenterol. 2014 Nov 14;20(42):15539-48
pubmed: 25400438
Nutr Metab Cardiovasc Dis. 2017 Oct;27(10):910-918
pubmed: 28821417
Int J Prev Med. 2015 Sep 01;6:82
pubmed: 26445629
J Agric Food Chem. 2012 Jun 27;60(25):6418-24
pubmed: 22656066
Molecules. 2009 Jan 05;14(1):200-9
pubmed: 19127248
Clin Nutr. 2014 Apr;33(2):186-90
pubmed: 24262589
Int J Mol Sci. 2019 Nov 25;20(23):
pubmed: 31775341
Biol Sex Differ. 2015 Sep 03;6:14
pubmed: 26339468
J Med Food. 2018 Mar;21(3):233-243
pubmed: 29356583
J AOAC Int. 2005 Sep-Oct;88(5):1269-78
pubmed: 16385975
J Agric Food Chem. 2021 Apr 21;69(15):4453-4463
pubmed: 33844520
BMC Pharmacol. 2004 Apr 19;4:5
pubmed: 15096274
Curr Opin Lipidol. 2008 Dec;19(6):572-8
pubmed: 18957879
Biochimie. 2014 Mar;98:86-101
pubmed: 24287293
Biomed Rep. 2020 Oct;13(4):30
pubmed: 32802327
Molecules. 2019 Jan 31;24(3):
pubmed: 30709014
Neurobiol Aging. 2013 Aug;34(8):1977-87
pubmed: 23545425
Biomed Res Int. 2013;2013:408573
pubmed: 23971034
Int J Mol Sci. 2015 Jan 22;16(2):2352-65
pubmed: 25622252
J Gastroenterol Hepatol. 2015 Jan;30(1):155-62
pubmed: 25041076