Disconnecting multicellular networks in brain tumours.

Brain Neoplasms / pathology Glioblastoma Humans

Journal

Nature reviews. Cancer
ISSN: 1474-1768
Titre abrégé: Nat Rev Cancer
Pays: England
ID NLM: 101124168

Informations de publication

Date de publication:
08 2022
Historique:
accepted: 24 03 2022
pubmed: 30 4 2022
medline: 29 7 2022
entrez: 29 4 2022
Statut: ppublish

Résumé

Cancer cells can organize and communicate in functional networks. Similarly to other networks in biology and sociology, these can be highly relevant for growth and resilience. In this Perspective, we demonstrate by the example of glioblastomas and other incurable brain tumours how versatile multicellular tumour networks are formed by two classes of long intercellular membrane protrusions: tumour microtubes and tunnelling nanotubes. The resulting networks drive tumour growth and resistance to standard therapies. This raises the question of how to disconnect brain tumour networks to halt tumour growth and whether this can make established therapies more effective. Emerging principles of tumour networks, their potential relevance for tumour types outside the brain and translational implications, including clinical trials that are already based on these discoveries, are discussed.

Identifiants

DOI: 10.1038/s41568-022-00475-0 PMID: 35488036
pubmed: 35488036
doi: 10.1038/s41568-022-00475-0
pii: 10.1038/s41568-022-00475-0
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

481-491

Informations de copyright

© 2022. Springer Nature Limited.

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Auteurs

Varun Venkataramani (V)

Neurology Clinic, University Hospital Heidelberg, Heidelberg, Germany. varun.venkataramani@med.uni-heidelberg.de.
National Center for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany. varun.venkataramani@med.uni-heidelberg.de.
Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. varun.venkataramani@med.uni-heidelberg.de.
Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany. varun.venkataramani@med.uni-heidelberg.de.
ORCID: 0000-0002-2927-0886

Matthias Schneider (M)

Department of Neurosurgery, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.

Frank Anton Giordano (FA)

Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany.

Thomas Kuner (T)

Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.

Wolfgang Wick (W)

Neurology Clinic, University Hospital Heidelberg, Heidelberg, Germany.
National Center for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Ulrich Herrlinger (U)

Division of Clinical Neurooncology, Department of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany. ulrich.herrlinger@ukbonn.de.
ORCID: 0000-0002-4011-9327

Frank Winkler (F)

Neurology Clinic, University Hospital Heidelberg, Heidelberg, Germany. frank.winkler@med.uni-heidelberg.de.
National Center for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany. frank.winkler@med.uni-heidelberg.de.
Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. frank.winkler@med.uni-heidelberg.de.
ORCID: 0000-0003-4892-6104

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Disconnecting multicellular networks in brain tumours.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Disconnecting multicellular networks in brain tumours.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Disconnecting multicellular networks in brain tumours.