Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts.
breast cancer
docosahexaenoic acid
necroptosis
patient derived xenograft
tumor
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
19
12
2020
revised:
04
10
2021
accepted:
18
03
2022
pubmed:
1
5
2022
medline:
2
8
2022
entrez:
30
4
2022
Statut:
ppublish
Résumé
Docosahexaenoic acid (DHA) reduces breast cancer tumor growth in preclinical models. To better understand how DHA amplifies the actions of docetaxel (TXT) chemotherapy, we examined the effects of two doses of dietary DHA on tumor size, membrane DHA content and necroptosis using a drug resistant triple negative breast cancer (TNBC) patient derived xenograft (PDX) model. Female NOD.Cb-Prkdc
Identifiants
pubmed: 35489658
pii: S0955-2863(22)00089-4
doi: 10.1016/j.jnutbio.2022.109018
pii:
doi:
Substances chimiques
Phospholipids
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Randomized Controlled Trial, Veterinary
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109018Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2022. Published by Elsevier Inc.