Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays.

ATP Binding Cassette Transporter, Subfamily B / metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism Animals Biological Transport / physiology Digoxin / metabolism Swine Transcytosis

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
07 2022
Historique:
received: 08 12 2021
accepted: 04 04 2022
pubmed: 1 5 2022
medline: 2 7 2022
entrez: 30 4 2022
Statut: ppublish

Résumé

The multidrug resistance protein 1 (MDR1) P-glycoprotein (P-gp) is a clinically important transporter. In vitro P-gp inhibition assays have been routinely conducted to predict the potential for clinical drug-drug interactions (DDIs) mediated by P-gp. However, high interlaboratory and intersystem variability of P-gp IC

Identifiants

DOI: 10.1124/dmd.121.000807 PMID: 35489778
pubmed: 35489778
pii: dmd.121.000807
doi: 10.1124/dmd.121.000807
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B 0
ATP Binding Cassette Transporter, Subfamily B, Member 1 0
Digoxin 73K4184T59

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

909-922

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Jocelyn Yabut (J)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Robert Houle (R)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Shubing Wang (S)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Andy Liaw (A)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Ravi Katwaru (R)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Hannah Collier (H)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Lucinda Hittle (L)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey.

Xiaoyan Chu (X)

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (J.Y., R.H., R.K., H.C., L.H., X.C.), and Department of Biometrics Research (S.W., A.L.), Merck & Co., Inc., Kenilworth, New Jersey xiaoyan_chu@merck.com.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Glycoprotéine P › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Eucaryotes › Animaux › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Métabolisme › Transport biologique › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides cardiotoniques › Glucosides digitaliques › Digoxine › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Selection of an Optimal In Vitro Model to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Transcytose › Selection of an Optimal In Vitro Model to...