Unconventional secretion mediated by direct protein self-translocation across the plasma membranes of mammalian cells.
fibroblast growth factor 2 (FGF2)
glypican-1 (GPC1)
membrane nanodomains
protein translocation
unconventional protein secretion (UPS)
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
22
12
2021
revised:
22
03
2022
accepted:
01
04
2022
pubmed:
1
5
2022
medline:
20
7
2022
entrez:
30
4
2022
Statut:
ppublish
Résumé
In recent years, a surprisingly complex picture emerged about endoplasmic reticulum (ER)/Golgi-independent secretory pathways, and several routes have been discovered that differ with regard to their molecular mechanisms and machineries. Fibroblast growth factor 2 (FGF2) is secreted by a pathway of unconventional protein secretion (UPS) that is based on direct self-translocation across the plasma membrane. Building on previous research, a component of this process has been identified to be glypican-1 (GPC1), a GPI-anchored heparan sulfate proteoglycan located on cell surfaces. These findings not only shed light on the molecular mechanism underlying this process but also reveal an intimate relationship between FGF2 and GPC1 that might be of critical relevance for the prominent roles they both have in tumor progression and metastasis.
Identifiants
pubmed: 35490075
pii: S0968-0004(22)00086-X
doi: 10.1016/j.tibs.2022.04.001
pii:
doi:
Substances chimiques
Fibroblast Growth Factor 2
103107-01-3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-709Informations de copyright
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