Trimester-specific prenatal heavy metal exposures and sex-specific postpartum size and growth.
Child exposure/health
Children’s health
Early life exposure
Metals
Vulnerable populations
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
05
11
2021
accepted:
14
04
2022
revised:
11
04
2022
medline:
22
12
2023
pubmed:
1
5
2022
entrez:
30
4
2022
Statut:
ppublish
Résumé
There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth. We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs. Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored. Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC. We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth. We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
Sections du résumé
BACKGROUND
BACKGROUND
There has been limited research considering the effects of prenatal exposure to multiple heavy metals on early childhood size and growth.
OBJECTIVE
OBJECTIVE
We evaluated prenatal exposures to 15 heavy metals in association with measures of weight, length, and head circumference (HC) measured at birth, and 1, 3 and 6 months of age in a study of 358 mother-child pairs.
METHODS
METHODS
Urinary concentrations were measured in the first and third trimesters of pregnancy and examined, using sex-stratified general linear models, in association with average standardized size and changes in size (growth) over the first 6 months of life. Confounding effects among metals were explored.
RESULTS
RESULTS
Increased first trimester Hg and V were associated with decreased average HC among males and weight among females, respectively. Increased first trimester V was associated with a decline in weight among females over time. Increased third trimester Cs, Rb and Tl were associated with increased average weight and HC among males. Increased third trimester Se was associated with increased HC among females over time. Evidence for confounding was observed between Cs, Rb and Tl in association with weight and HC.
SIGNIFICANCE
CONCLUSIONS
We observed multiple biologically plausible associations between prenatal heavy metal exposures and postnatal size and growth.
IMPACT
CONCLUSIONS
We have taken a comprehensive and novel approach to evaluating the impacts of prenatal heavy metal exposures on size and growth during early childhood. Our detailed analyses consider exposures to 15 different heavy metals at two time points during pregnancy, as well as multiple metrics of size and growth collected at birth and 1, 3 and 6 months of age.
Identifiants
pubmed: 35490160
doi: 10.1038/s41370-022-00443-8
pii: 10.1038/s41370-022-00443-8
pmc: PMC9617807
mid: NIHMS1798644
doi:
Substances chimiques
Metals, Heavy
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-902Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES025796
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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