CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignancies.
Apcin
CDC20
Hematological malignancies
Mitotic checkpoint
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
30 Apr 2022
30 Apr 2022
Historique:
received:
14
01
2022
accepted:
11
04
2022
entrez:
30
4
2022
pubmed:
1
5
2022
medline:
4
5
2022
Statut:
epublish
Résumé
Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20 in cancer development, as alterations of its functionality have been linked to genomic instability and evidence demonstrated that high CDC20 expression levels are associated with poor overall survival in solid cancers. More recently, novel CDC20 functions have been demonstrated or suggested, including the regulation of apoptosis and stemness properties and a correlation with immune cell infiltration. Here, we here summarize and discuss the role of CDC20 inside and outside mitosis, starting from its network of interacting proteins. In the last years, CDC20 has also attracted more interest in the blood cancer field, being overexpressed and showing an association with prognosis both in myeloid and lymphoid malignancies. Preclinical findings showed that selective CDC20 and APC/C
Identifiants
pubmed: 35490245
doi: 10.1186/s13046-022-02363-9
pii: 10.1186/s13046-022-02363-9
pmc: PMC9055704
doi:
Substances chimiques
Cdc20 Proteins
0
Cell Cycle Proteins
0
CDC20 protein, human
156288-95-8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
159Subventions
Organisme : ERA-Per-Med
ID : ERAPERMED2018-275
Informations de copyright
© 2022. The Author(s).
Références
J Biol Chem. 2021 Aug;297(2):100986
pubmed: 34298015
Med Oncol. 2015 Mar;32(3):81
pubmed: 25698537
J Med Chem. 2020 May 14;63(9):4685-4700
pubmed: 32290657
Elife. 2014 Aug 19;3:e03083
pubmed: 25139956
Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):105-116
pubmed: 28939057
EMBO Rep. 2012 Apr;13(4):347-54
pubmed: 22322943
Cell Death Dis. 2014 Jun 12;5:e1291
pubmed: 24922075
Mol Cell. 2010 May 14;38(3):383-92
pubmed: 20471944
Leukemia. 2020 Apr;34(4):966-984
pubmed: 32127639
PeerJ. 2020 Mar 20;8:e8843
pubmed: 32219041
J Biol Chem. 2004 Jul 30;279(31):31991-4
pubmed: 15090550
Sci Rep. 2020 Feb 17;10(1):2706
pubmed: 32066746
Int J Cancer. 2019 Jan 1;144(1):8-25
pubmed: 29981145
Nature. 1999 Nov 11;402(6758):203-7
pubmed: 10647015
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1201-6
pubmed: 17227844
Curr Biol. 2012 May 22;22(10):900-6
pubmed: 22521787
Blood Cancer J. 2020 Aug 11;10(8):82
pubmed: 32782240
Chem Biol Interact. 2010 Jan 5;183(1):222-30
pubmed: 19781537
J Cell Biol. 2013 Apr 15;201(2):217-31
pubmed: 23569217
Cell Death Dis. 2013 Oct 03;4:e834
pubmed: 24091677
Cancer Cell. 2010 Oct 19;18(4):382-95
pubmed: 20951947
Leuk Res. 2014 Feb;38(2):218-24
pubmed: 24314588
Cancer. 2019 Mar 1;125(5):712-725
pubmed: 30480765
Prostate. 2014 Jul;74(10):999-1011
pubmed: 24802614
Nat Chem Biol. 2020 May;16(5):546-555
pubmed: 32152539
Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118929
pubmed: 33310066
EMBO J. 2010 Jul 21;29(14):2407-20
pubmed: 20526282
Dev Cell. 2014 May 27;29(4):377-91
pubmed: 24871945
Development. 2014 Apr;141(7):1453-64
pubmed: 24598157
Nature. 2014 Oct 30;514(7524):646-9
pubmed: 25156254
Nat Commun. 2016 Feb 25;7:10818
pubmed: 26912231
Cell Biochem Funct. 2010 Jun;28(4):249-57
pubmed: 20517887
J Surg Oncol. 2012 Sep 15;106(4):423-30
pubmed: 22488197
Mol Ther Oncolytics. 2021 Jul 29;22:431-443
pubmed: 34553030
Oncogene. 2010 Jun 17;29(24):3501-8
pubmed: 20418911
PLoS One. 2011;6(11):e27583
pubmed: 22132115
Science. 2009 Mar 6;323(5919):1350-3
pubmed: 19150808
Br J Cancer. 2014 Jun 10;110(12):2905-13
pubmed: 24853182
Genes (Basel). 2020 Feb 20;11(2):
pubmed: 32093406
Clin Cancer Res. 2003 Mar;9(3):991-7
pubmed: 12631597
Genes Dev. 2007 Oct 1;21(19):2385-98
pubmed: 17908926
EMBO J. 2001 Dec 17;20(24):7117-27
pubmed: 11742988
Mol Med Rep. 2017 Apr;15(4):1661-1667
pubmed: 28260099
Nat Med. 2019 Mar;25(3):530
pubmed: 30705421
Cold Spring Harb Symp Quant Biol. 2005;70:233-40
pubmed: 16869759
Leuk Res. 2007 Jun;31(6):839-51
pubmed: 17023045
Nat Commun. 2019 Aug 27;10(1):3863
pubmed: 31455778
Cell Biochem Funct. 2020 Aug;38(6):810-816
pubmed: 32458533
J Cell Biol. 2010 Oct 18;191(2):313-29
pubmed: 20956380
Nat Cell Biol. 1999 Jun;1(2):82-7
pubmed: 10559878
J Cell Biol. 2013 Jun 24;201(7):1013-26
pubmed: 23775192
Cell Cycle. 2018;17(1):43-52
pubmed: 28980876
Dev Cell. 2015 Feb 9;32(3):358-372
pubmed: 25669885
Haematologica. 2013 Dec;98(12):1886-95
pubmed: 23812934
J Cell Sci. 2002 Mar 1;115(Pt 5):949-61
pubmed: 11870214
Int J Biol Sci. 2021 Aug 19;17(13):3608-3621
pubmed: 34512169
Mol Cell Biol. 2003 Aug;23(15):5269-81
pubmed: 12861013
PLoS Genet. 2020 Nov 2;16(11):e1009184
pubmed: 33137813
Biosci Rep. 2019 Jan 3;39(1):
pubmed: 30393234
Oncogene. 2008 Mar 6;27(11):1562-71
pubmed: 17873905
J Natl Cancer Inst. 2013 Oct 2;105(19):1463-73
pubmed: 24052624
Biol Open. 2015 Dec 18;5(1):11-9
pubmed: 26685311
Annu Rev Genet. 2001;35:673-745
pubmed: 11700297
Cell Rep. 2015 Jun 23;11(11):1809-21
pubmed: 26074073
Curr Protoc. 2021 Mar;1(3):e90
pubmed: 33780170
Am J Cancer Res. 2017 May 01;7(5):1016-1036
pubmed: 28560055
Cell. 2016 Nov 3;167(4):1028-1040.e15
pubmed: 27881301
Theranostics. 2018 Nov 15;8(21):5995-6007
pubmed: 30613277
Nat Rev Cancer. 2017 Jan 27;17(2):93-115
pubmed: 28127048
Nature. 2016 Aug 25;536(7617):431-436
pubmed: 27509861
Nat Commun. 2015 Oct 01;6:8399
pubmed: 26423134
Dev Cell. 2001 Aug;1(2):227-37
pubmed: 11702782
J Cell Biol. 2013 Dec 23;203(6):943-55
pubmed: 24344183
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18419-24
pubmed: 23091007
Leuk Res. 2018 Jan;64:61-70
pubmed: 29220700
Nan Fang Yi Ke Da Xue Xue Bao. 2018 Mar 20;38(3):261-267
pubmed: 29643030
Nat Cell Biol. 2012 Jun 03;14(7):746-52
pubmed: 22660415
Cancer Cell. 2011 Oct 18;20(4):487-99
pubmed: 22014574
EMBO J. 2003 Dec 15;22(24):6598-609
pubmed: 14657031
J Cell Biol. 2010 Jul 12;190(1):25-34
pubmed: 20624899
Mol Cell. 2007 Jul 6;27(1):3-16
pubmed: 17612486
Blood. 2014 Sep 11;124(11):1790-8
pubmed: 25006131
Science. 2009 Oct 23;326(5952):575-8
pubmed: 19900895
J Assist Reprod Genet. 2021 May;38(5):993-1002
pubmed: 33895934
J Invest Dermatol. 2018 Aug;138(8):1851-1861
pubmed: 29526760
Molecules. 2021 Jan 28;26(3):
pubmed: 33525621
Invest New Drugs. 2021 Oct;39(5):1439-1453
pubmed: 33942202
Curr Biol. 2016 Oct 10;26(19):2642-2650
pubmed: 27618268
J Hematol Oncol. 2012 Apr 04;5:15
pubmed: 22475564
Cell. 2008 May 16;133(4):653-65
pubmed: 18485873
Oncotarget. 2016 Feb 2;7(5):5176-92
pubmed: 26769847
Mol Ther Oncolytics. 2020 Mar 30;17:94-106
pubmed: 32322666
EMBO J. 2001 Feb 15;20(4):792-801
pubmed: 11179223
Aging Cell. 2020 Nov;19(11):e13251
pubmed: 33094908
Genome Med. 2015 Jan 28;7(1):8
pubmed: 25632304
Neoplasma. 2021 Mar;68(2):382-390
pubmed: 33118830
Chromosoma. 2004 Aug;113(1):1-15
pubmed: 15235793
Curr Biol. 2012 May 22;22(10):891-9
pubmed: 22521786
Leukemia. 2005 Dec;19(12):2264-72
pubmed: 16208411
Int J Oncol. 2012 Feb;40(2):418-26
pubmed: 22002244
J Cell Biochem. 2009 Jul 1;107(4):686-96
pubmed: 19347873
J Biol Chem. 2013 Dec 6;288(49):35149-58
pubmed: 24151075
Biochem Biophys Res Commun. 2013 Jun 21;436(1):12-8
pubmed: 23643811
Nat Chem Biol. 2012 Feb 26;8(4):383-92
pubmed: 22366722
J Cell Mol Med. 2021 Dec;25(24):11128-11141
pubmed: 34726341
Cell Death Dis. 2017 Jun 15;8(6):e2882
pubmed: 28617439
Carcinogenesis. 2013 Apr;34(4):750-9
pubmed: 23239745
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 23028116
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):63-8
pubmed: 15623561
J Ovarian Res. 2020 Jan 27;13(1):10
pubmed: 31987036
Cell Cycle. 2016 Sep;15(17):2275-87
pubmed: 27097363
Mol Cell. 2015 Oct 1;60(1):21-34
pubmed: 26387737
Cell Rep. 2018 May 1;23(5):1461-1475
pubmed: 29719258
Cell Death Differ. 2020 Aug;27(8):2451-2467
pubmed: 32080348
J Clin Pathol. 2015 May;68(5):381-7
pubmed: 25637637
Curr Pharm Des. 2013;19(18):3210-4
pubmed: 23151139
Curr Biol. 2012 Nov 20;22(22):R966-80
pubmed: 23174302
Oncotarget. 2017 Jun 27;8(26):42983-42996
pubmed: 28562334
Proc Natl Acad Sci U S A. 1970 Jun;66(2):352-9
pubmed: 5271168
Oncotarget. 2016 Oct 25;7(43):70481-70493
pubmed: 27655696
Science. 2021 Jan 1;371(6524):67-71
pubmed: 33384373
EMBO J. 2018 Sep 3;37(17):
pubmed: 29987118
Mol Cancer Ther. 2016 Jul;15(7):1682-90
pubmed: 27196769
Cancer Res. 2014 Feb 15;74(4):1079-90
pubmed: 24371226
Mol Cell Biol. 2007 May;27(9):3481-8
pubmed: 17325031
Mol Cell. 2007 Aug 3;27(3):462-73
pubmed: 17679094
Cell Biochem Funct. 2020 Jun;38(4):451-459
pubmed: 31945194
Clin Cancer Res. 2006 Jan 15;12(2):405-10
pubmed: 16428479
J Cell Biol. 2001 Apr 2;153(1):137-48
pubmed: 11285280
Int J Oncol. 2014 Oct;45(4):1547-55
pubmed: 25069850
J Biol Chem. 2019 Jun 28;294(26):10236-10252
pubmed: 31101654
Oncogene. 2006 Apr 27;25(18):2575-87
pubmed: 16407851
Mol Cell Biol. 2006 Oct;26(20):7420-9
pubmed: 17015473
Blood Adv. 2019 Feb 26;3(4):552-563
pubmed: 30782614
Front Oncol. 2021 Aug 30;11:721797
pubmed: 34527589
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Cell Cycle. 2013 Jan 15;12(2):365-78
pubmed: 23287467
Trends Cell Biol. 2019 Feb;29(2):117-134
pubmed: 30482618
Pharmacol Ther. 2015 Jul;151:141-51
pubmed: 25850036
Mol Biol Cell. 2000 May;11(5):1555-69
pubmed: 10793135
Onco Targets Ther. 2020 Oct 15;13:10475-10487
pubmed: 33116627
EMBO Rep. 2020 Jun 4;21(6):e50494
pubmed: 32431068
J Cell Biol. 2009 Jun 15;185(6):983-94
pubmed: 19528295
Int J Clin Oncol. 2019 Nov;24(11):1479-1489
pubmed: 31278532
Elife. 2013 Sep 24;2:e01030
pubmed: 24066227
J Hematol Oncol. 2019 Nov 26;12(1):123
pubmed: 31771633
Nature. 2012 Mar 21;484(7393):208-13
pubmed: 22437499
Cell. 2007 Nov 16;131(4):730-43
pubmed: 18022367
Mol Cell Oncol. 2018 Oct 11;5(6):e1516450
pubmed: 30525093
Protein Sci. 2021 Jan;30(1):187-200
pubmed: 33070389
Int J Cancer. 2020 Feb 15;146(4):1086-1098
pubmed: 31286496
Oncotarget. 2016 Jan 26;7(4):4062-76
pubmed: 26716651
Cell Mol Life Sci. 2021 Jun;78(11):4955-4972
pubmed: 33860332
J Cell Sci. 2010 Mar 15;123(Pt 6):825-35
pubmed: 20200228
Cold Spring Harb Perspect Biol. 2013 Mar 01;5(3):a008904
pubmed: 23457258
Virchows Arch. 2008 Dec;453(6):599-609
pubmed: 18953566
Int J Mol Sci. 2020 Sep 12;21(18):
pubmed: 32932732
EMBO Rep. 2020 Jan 7;21(1):e48503
pubmed: 31825153
Br J Cancer. 2019 Jun;120(12):1137-1146
pubmed: 31089208