ALA-iPDT for follicular occlusion tetrad concomitant with pachyonychia congenital type Ⅱ and ankylosing spondylitis.
Follicular occlusion tetrad
KRT17
Pachyonychia congenital
Photodynamic therapy
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
10
02
2022
revised:
17
04
2022
accepted:
27
04
2022
pubmed:
2
5
2022
medline:
9
9
2022
entrez:
1
5
2022
Statut:
ppublish
Résumé
The follicular occlusion tetrad is a complex dermatologic syndrome which can concomitant with other diseases. The case reported a young male patient suffer from follicular occlusion tetrad (acne conglobata, hidradenitis suppurativa, dissecting cellulitis of the scalp, and pilonidal sinuses) concomitant with pachyonychia congenital type Ⅱ (thickened nails, palmoplantar keratoderma, multiple cysts) and ankylosing spondylitis (lumbago, human leukocyte antigen-B27 positive). The genetic analysis showed the KRT17 gene mutation on exon 1 (c.T284C) supports the diagnosis. Whereupon, a comprehensive therapy scheme of 5-aminolevulinic acid-mediated interstitial photodynamic therapy (ALA-iPDT) combined with surgery offered excellent response. This case reports a rare condition and proposes a therapeutic option that may work.
Identifiants
pubmed: 35490959
pii: S1572-1000(22)00177-6
doi: 10.1016/j.pdpdt.2022.102891
pii:
doi:
Substances chimiques
Aminolevulinic Acid
88755TAZ87
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
102891Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors declare that there is no conflict of interest.