A phase 1b study of atezolizumab in combination with guadecitabine for the treatment of acute myeloid leukemia.

Aged Antibodies, Monoclonal, Humanized / adverse effects Antineoplastic Combined Chemotherapy Protocols / adverse effects Azacitidine / analogs & derivatives Humans Leukemia, Myeloid, Acute / diagnosis
Oncology PD-L1 inhibitor checkpoint inhibitor

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
Sep 2022
Historique:
pubmed: 3 5 2022
medline: 12 10 2022
entrez: 2 5 2022
Statut: ppublish

Résumé

This phase 1 b study evaluated the safety, efficacy, and pharmacokinetics of atezolizumab in combination with guadecitabine in patients with relapsed/refractory (R/R) or first-line acute myeloid leukemia (AML). Patients received atezolizumab 840 mg (days [D] 8 and 22) and guadecitabine 60 mg/m

Identifiants

DOI: 10.1080/10428194.2022.2057484 PMID: 35491816
pubmed: 35491816
doi: 10.1080/10428194.2022.2057484
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
guadecitabine 2KT4YN1DP7
atezolizumab 52CMI0WC3Y
Azacitidine M801H13NRU

Types de publication

Clinical Trial, Phase I Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2180-2188

Auteurs

Thomas Prebet (T)

Hematology, Yale University, New Haven, Connecticut, United States.
ORCID: 0000-0002-6872-625X

Aaron D Goldberg (AD)

Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Joseph G Jurcic (JG)

Columbia University Irving Medical Center, New York, New York, United States.

Samer Khaled (S)

City of Hope, Duarte, California, United States.

Monique Dail (M)

Genentech, Inc, South San Francisco, California, United States.

Yuning Feng (Y)

Genentech, Inc, South San Francisco, California, United States.

Cherie Green (C)

Genentech, Inc, South San Francisco, California, United States.

Chunze Li (C)

Genentech, Inc, South San Francisco, California, United States.

Connie Ma (C)

Genentech, Inc, South San Francisco, California, United States.

Bruno C Medeiros (BC)

Genentech, Inc, South San Francisco, California, United States.

Mark Yan (M)

Hoffmann-La Roche Ltd, Mississauga, Ontario, Canada.

Michael R Grunwald (MR)

Levine Cancer Institute, Atrium Health, Charlotte, North Carolina, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A phase 1b study of atezolizumab in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › A phase 1b study of atezolizumab in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Protocoles de polychimiothérapie antinéoplasique › A phase 1b study of atezolizumab in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Cytidine › Azacitidine › A phase 1b study of atezolizumab in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A phase 1b study of atezolizumab in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › A phase 1b study of atezolizumab in...