Left Atrial Remodeling and Stroke in Patients With Sinus Rhythm and Normal Ejection Fraction: ARIC-NCS.
3‐dimensional echocardiography
left atrial function
left atrial stiffness
left atrial strain
subclinical cerebral infarctions
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 05 2022
03 05 2022
Historique:
pubmed:
3
5
2022
medline:
6
5
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
Background Age-related left atrial (LA) structural and functional abnormalities may be related to subclinical cerebral infarcts (SCIs) and stroke. We evaluated the association of 3-dimensional echocardiographic LA contractility parameters with SCIs and stroke across the spectrum of tertiles of age increment in elderly patients with sinus rhythm, normal ejection fraction, and no history of atrial fibrillation. Methods and Results We enrolled 407 participants (mean age, 76±8 years; 40% men) from ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study) undergoing a brain magnetic resonance imaging and 3-dimensional echocardiographic examinations in 2011 to 2013. The sample was analyzed among age tertiles and subgroups: no cerebral magnetic resonance imaging-detectable infarcts (n=315), magnetic resonance imaging-diagnosed SCIs (n=58), and clinically diagnosed stroke (n=34). The frequency of SCIs significantly increased over age tertiles (
Identifiants
pubmed: 35491988
doi: 10.1161/JAHA.121.024292
pmc: PMC9238625
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024292Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL126637
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100007C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100011C
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS127266
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100009C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100006C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL158022
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100010C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100012C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100008C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135008
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL155813
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070825
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL148521
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL152008
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141288
Pays : United States
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