The effect of the delta SARS-CoV-2 variant on maternal infection and pregnancy.
Pregnancy
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 May 2022
20 May 2022
Historique:
pubmed:
3
5
2022
medline:
3
5
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
A greater proportion of pregnant women with COVID-19 have mild disease compared with their non-pregnant counterparts. Paradoxically, however, they are at higher risk of developing severe disease, requiring respiratory support and admission to intensive care. The delta SARS-Cov-2 variant is associated with increased risk of hospitalization and morbidity in unvaccinated pregnant populations. However, it is not known whether the worse pregnancy outcomes associated with the delta variant are due to a direct effect of the virus on the pregnancy, or whether this effect is mediated through more severe maternal infection. Here, we synthesize studies of COVID-19 pregnancies, focusing on the different routes of SARS-CoV-2 infection of lung and placenta, and the mechanisms of syncytial formation for each SARS-CoV-2 variant. To delineate COVID-19 complications in pregnant women, future studies should explore whether the delta variant causes greater placental infection compared to other variants and contributes to increased syncytial formation.
Identifiants
pubmed: 35492217
doi: 10.1016/j.isci.2022.104295
pii: S2589-0042(22)00565-X
pmc: PMC9040522
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
104295Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors have no interest to declare.
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