Transcriptome and metabolome changes induced by bitter melon (
AMPK, adenosine monophosphate-activated protein kinase
BMJ, bitter melon juice
Bitter melon
DIO, diet-induced obese
Diet intervention
HDL, high density lipoprotein (cholesterol)
HFD, high fat diet
HMDB, Human Metabolome Database
High fat diet-induced obesity
KEGG, Kyoto Encyclopedia of Genes and Genomes
LC-MS, liquid-chromatography mass spectrometry
LDL, low density lipoprotein (cholesterol)
MetS, Metabolic syndrome
Metabolic syndrome
Momordica charantia
PC, phosphatidylcholine
PE, phosphatidylethanolamine
PPARs, Peroxisome proliferator-activated receptors
Journal
Journal of traditional and complementary medicine
ISSN: 2225-4110
Titre abrégé: J Tradit Complement Med
Pays: Netherlands
ID NLM: 101605474
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
22
07
2021
revised:
16
08
2021
accepted:
16
08
2021
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Metabolic syndrome (MetS) is a complex disease of physiological imbalances interrelated to abnormal metabolic conditions, such as abdominal obesity, type II diabetes, dyslipidemia and hypertension. In the present pilot study, we investigated the nutraceutical bitter melon ( Metabolic effects of lyophilized bitter melon juice (BMJ) extract (oral gavage 200 mg/kg/body weight-daily for 40 days) intake were evaluated in diet-induced obese C57BL/6J male mice [fed-high fat diet (HFD), 60 kcal% fat]. Changes in BMJ-mediated changes showed a positive trend towards enhanced glucose homeostasis, vitamin D metabolism and suppression of glycerophospholipid metabolism. In the liver, nuclear peroxisome proliferator-activated receptor (PPAR) and circadian rhythm signaling, as well as bile acid biosynthesis and glycogen metabolism targets were modulated by BMJ (p < 0.05). Thus, our in-depth transcriptomics and metabolomics analysis suggests that BMJ-intake lowers susceptibility to the onset of high-fat diet associated MetS risk factors partly through modulation of PPAR signaling and its downstream targets in circadian rhythm processes to prevent excessive lipogenesis, maintain glucose homeostasis and modify immune responses signaling.
Sections du résumé
Background and aim
UNASSIGNED
Metabolic syndrome (MetS) is a complex disease of physiological imbalances interrelated to abnormal metabolic conditions, such as abdominal obesity, type II diabetes, dyslipidemia and hypertension. In the present pilot study, we investigated the nutraceutical bitter melon (
Experimental procedure
UNASSIGNED
Metabolic effects of lyophilized bitter melon juice (BMJ) extract (oral gavage 200 mg/kg/body weight-daily for 40 days) intake were evaluated in diet-induced obese C57BL/6J male mice [fed-high fat diet (HFD), 60 kcal% fat]. Changes in
Results and conclusion
UNASSIGNED
BMJ-mediated changes showed a positive trend towards enhanced glucose homeostasis, vitamin D metabolism and suppression of glycerophospholipid metabolism. In the liver, nuclear peroxisome proliferator-activated receptor (PPAR) and circadian rhythm signaling, as well as bile acid biosynthesis and glycogen metabolism targets were modulated by BMJ (p < 0.05). Thus, our in-depth transcriptomics and metabolomics analysis suggests that BMJ-intake lowers susceptibility to the onset of high-fat diet associated MetS risk factors partly through modulation of PPAR signaling and its downstream targets in circadian rhythm processes to prevent excessive lipogenesis, maintain glucose homeostasis and modify immune responses signaling.
Identifiants
pubmed: 35493312
doi: 10.1016/j.jtcme.2021.08.011
pii: S2225-4110(21)00103-6
pmc: PMC9039170
doi:
Types de publication
Journal Article
Langues
eng
Pagination
287-301Informations de copyright
© 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.
Déclaration de conflit d'intérêts
None.
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