TIM-3 Expression Level on AML Blasts Correlates With Presence of Core Binding Factor Translocations Rather Than Clinical Outcomes.
TIM-3
acute myeloid leukemia
core binding factor translocation
flow cytometry
prognosis
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
02
2022
accepted:
18
03
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) expresses on leukemic stem and progenitor populations of non-M3 acute myeloid leukemia (AML) as well as T lymphocytes. TIM-3 is thought to be involved in the self-renewal of leukemic stem cells and the immune escape of AML cells, however its correlation with AML prognosis is still controversial and worthy of further investigation. we simultaneously assessed TIM-3 expression levels of leukemic blasts and T lymphocytes in the bone marrow of TIM-3 expression of CD34 TIM-3 expression level on AML blasts correlates with presence of CBF translocations rather than clinical outcomes.
Sections du résumé
Background
UNASSIGNED
T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) expresses on leukemic stem and progenitor populations of non-M3 acute myeloid leukemia (AML) as well as T lymphocytes. TIM-3 is thought to be involved in the self-renewal of leukemic stem cells and the immune escape of AML cells, however its correlation with AML prognosis is still controversial and worthy of further investigation.
Methods
UNASSIGNED
we simultaneously assessed TIM-3 expression levels of leukemic blasts and T lymphocytes in the bone marrow of
Results
UNASSIGNED
TIM-3 expression of CD34
Conclusion
UNASSIGNED
TIM-3 expression level on AML blasts correlates with presence of CBF translocations rather than clinical outcomes.
Identifiants
pubmed: 35494006
doi: 10.3389/fonc.2022.879471
pmc: PMC9046698
doi:
Types de publication
Journal Article
Langues
eng
Pagination
879471Informations de copyright
Copyright © 2022 Hong, Xia, Huang, Yuan, Liang, Dai, Wu, Liang, Ruan, Long, Cheng, Chen, Ni, Ge, Li, Zeng, Xia, Wang and Yang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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