Resilience integrates concepts in aging research.
Biological sciences
Cell biology
Evolutionary biology
Health sciences
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 May 2022
20 May 2022
Historique:
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.
Identifiants
pubmed: 35494229
doi: 10.1016/j.isci.2022.104199
pii: S2589-0042(22)00469-2
pmc: PMC9044173
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
104199Subventions
Organisme : BLRD VA
ID : I01 BX003846
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067330
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG074503
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133428
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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