Collagen-curcumin nanocomposites showing an enhanced neuroprotective effect against short term focal cerebral ischemia.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
08 Jan 2020
08 Jan 2020
Historique:
received:
17
10
2019
accepted:
05
01
2020
entrez:
2
5
2022
pubmed:
10
1
2020
medline:
10
1
2020
Statut:
epublish
Résumé
The effectiveness of curcumin in treating cerebral ischemia has been reported in recent studies. However, its mode of action is still not defined. The objective of the present study is to formulate collagen-curcumin nanocomposites which will work effectively against cerebral ischemia/reperfusion injury. Ischemic injury is followed by inflammatory damage and oxidative stress, which together contribute a lot in the pathogenesis of cerebral ischemia and may be considered a good target for treatment. The present study focused on examining the effectiveness of collagen-curcumin nanocomposites stabilized by increasing the degree of crosslinking in reducing oxidative stress associated with brain injury resulting from cerebral ischemia. The collagen nanoparticles were prepared by conjugating collagen on the surface of Tween©80 micelles, and further stabilizing them using crosslinkers. The effectiveness of the prepared nanocomposite was validated by performing infarct analysis followed by biochemical, behavioral, histopathological and immunohistochemical studies. The outcomes of this study are promising for the use of collagen-curcumin nanocomposites in showing neuroprotective potential in treating ischemic injury.
Identifiants
pubmed: 35494586
doi: 10.1039/c9ra08508d
pii: c9ra08508d
pmc: PMC9048592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2241-2253Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
Références
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10824-9
pubmed: 10485910
Drug Discov Today. 2007 Jan;12(1-2):54-61
pubmed: 17198973
Indian J Biochem Biophys. 2011 Apr;48(2):73-81
pubmed: 21682137
Diabetes. 2000 Jun;49(6):1006-15
pubmed: 10866054
Biochem Pharmacol. 1984 Jun 1;33(11):1801-7
pubmed: 6145422
Evid Based Complement Alternat Med. 2011;2011:519517
pubmed: 18955358
Cell Mol Biol (Noisy-le-grand). 2013 Dec 31;59 Suppl:OL1899-905
pubmed: 24461330
Trends Neurosci. 1999 Sep;22(9):391-7
pubmed: 10441299
J Neurochem. 2003 Feb;84(3):438-46
pubmed: 12558963
Annu Rev Immunol. 1994;12:141-79
pubmed: 8011280
J Biol Chem. 1995 Oct 20;270(42):24995-5000
pubmed: 7559628
Cell Mol Life Sci. 2000 Mar;57(3):500-5
pubmed: 10823249
Stroke. 1989 Jan;20(1):84-91
pubmed: 2643202
Acta Pharmacol Sin. 2004 Dec;25(12):1606-12
pubmed: 15569404
Redox Biol. 2015 Dec;6:524-551
pubmed: 26484802
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):199-214
pubmed: 12657360
J Cereb Blood Flow Metab. 2001 Feb;21(2):99-109
pubmed: 11176275
Mol Cell Biochem. 1994 Aug 17;137(1):1-8
pubmed: 7845373
J Biosci. 2003 Dec;28(6):715-21
pubmed: 14660871
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):267-82
pubmed: 12657366
Trends Pharmacol Sci. 1998 Feb;19(2):59-66
pubmed: 9550943
Stroke. 2000 Apr;31(4):852-7
pubmed: 10753987
J Biol Chem. 1975 Jul 25;250(14):5475-80
pubmed: 237922
Clin Mater. 1992;9(3-4):139-48
pubmed: 10149963
Mol Cell Biochem. 2012 Aug;367(1-2):73-84
pubmed: 22669728
J Neurosci. 1999 May 15;19(10):3809-17
pubmed: 10234013
Neuroscience. 2006;137(1):241-51
pubmed: 16289892
Food Chem Toxicol. 1994 Mar;32(3):279-83
pubmed: 8157223
Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9618-22
pubmed: 7568184
Mol Med Rep. 2017 Oct;16(4):4710-4720
pubmed: 28849007
Pharmacology. 1974;11(3):151-69
pubmed: 4831804
J Pharm Pharmacol. 1973 Jun;25(6):447-52
pubmed: 4146582
Stroke. 2008 Jul;39(7):2091-8
pubmed: 18467652
Acta Pharmacol Sin. 2009 Aug;30(8):1071-80
pubmed: 19617892
Exp Neurol. 2005 May;193(1):75-84
pubmed: 15817266
Brain Res. 2009 Jul 28;1282:133-41
pubmed: 19445907
Behav Brain Funct. 2010 Oct 19;6:61
pubmed: 20955613
Carcinogenesis. 1999 Apr;20(4):641-4
pubmed: 10223193
Biomaterials. 2004 Jul;25(15):3065-71
pubmed: 14967540
J Biol Chem. 1974 Nov 25;249(22):7130-9
pubmed: 4436300
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5341-5
pubmed: 7777509
J Biol Chem. 2005 Feb 18;280(7):5892-901
pubmed: 15590663
J Neurol Sci. 2011 Oct 15;309(1-2):45-54
pubmed: 21840019