A Diagnosis of Idiopathic Hypereosinophilic Syndrome With Skin Involvement in a Patient Presenting With Lymphadenopathy and Rash.
cervical lymphadenopathy
heart failure
hypereosinophilia syndrome
imatinib mesylate
systemic steroids
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
28
03
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Idiopathic hypereosinophilic syndrome is a rare entity where the diagnosis is made after all the probable causes of hypereosinophilia are excluded. The characteristic organ involvement includes the heart, nervous system, lung, and gastrointestinal tract. The mainstay of treatment is corticosteroids. Patients who are unresponsive to the steroids require immunomodulatory therapy that includes imatinib, mepolizumab, and in some resistant cases alemtuzumab. We describe a case of idiopathic hypereosinophilic syndrome with skin involvement without other organ infiltration in a previously unevaluated South Asian male who responded well to the initiation of steroid therapy.
Identifiants
pubmed: 35494909
doi: 10.7759/cureus.23580
pmc: PMC9045841
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e23580Informations de copyright
Copyright © 2022, Sekar et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Haematologica. 2009 Sep;94(9):1188-93
pubmed: 19734412
Case Rep Oncol. 2021 Mar 2;14(1):249-255
pubmed: 33776712
Cureus. 2021 Nov 6;13(11):e19307
pubmed: 34900483