Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones.
Alkylation
Cesium bicarbonate
Regioselective
Scalable
Journal
Tetrahedron letters
ISSN: 0040-4039
Titre abrégé: Tetrahedron Lett
Pays: England
ID NLM: 2984819R
Informations de publication
Date de publication:
13 Apr 2022
13 Apr 2022
Historique:
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
ppublish
Résumé
We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.
Identifiants
pubmed: 35495552
doi: 10.1016/j.tetlet.2022.153755
pmc: PMC9053733
mid: NIHMS1795132
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI161313
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM066706
Pays : United States
Organisme : FIC NIH HHS
ID : T37 TW000090
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Competing Interest None
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