Papillary cystadenoma of the epididymis.
Case Reports
Cystadenoma, Papillary
Epididymis
von Hippel-Lindau Disease
Journal
Autopsy & case reports
ISSN: 2236-1960
Titre abrégé: Autops Case Rep
Pays: Brazil
ID NLM: 101640070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
01
2022
accepted:
29
03
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Papillary cystadenoma is a rare benign neoplasm of the epididymis. It may occur sporadically or in association with von Hippel-Lindau disease (VHLD). Papillary cystadenoma of the epididymis (PCE) is a benign mimic of metastatic clear cell renal cell carcinoma (CCRCC) given their histologic similarities. Herein, we present the case of a 40-year-old man with a four-year history of microhematuria and a recently detected right paratesticular mass. A testicular sonogram revealed a hypoechoic, hypervascular solid mass in the right epididymal head treated by surgical excision. Histopathological examination demonstrated a 1.1 cm papillary cystadenoma of the epididymis. Genetic testing performed later showed no signs of VHLD. However, heterozygous mutations in three genes - Papillary cystadenoma of the epididymis should always be considered in the differential diagnosis of epididymal lesions, especially those that are cystic. The mainstay of treatment remains surgical excision, which provides an excellent prognosis.
Sections du résumé
Background
UNASSIGNED
Papillary cystadenoma is a rare benign neoplasm of the epididymis. It may occur sporadically or in association with von Hippel-Lindau disease (VHLD). Papillary cystadenoma of the epididymis (PCE) is a benign mimic of metastatic clear cell renal cell carcinoma (CCRCC) given their histologic similarities.
Case presentation
UNASSIGNED
Herein, we present the case of a 40-year-old man with a four-year history of microhematuria and a recently detected right paratesticular mass. A testicular sonogram revealed a hypoechoic, hypervascular solid mass in the right epididymal head treated by surgical excision. Histopathological examination demonstrated a 1.1 cm papillary cystadenoma of the epididymis. Genetic testing performed later showed no signs of VHLD. However, heterozygous mutations in three genes -
Conclusions
UNASSIGNED
Papillary cystadenoma of the epididymis should always be considered in the differential diagnosis of epididymal lesions, especially those that are cystic. The mainstay of treatment remains surgical excision, which provides an excellent prognosis.
Identifiants
pubmed: 35496736
doi: 10.4322/acr.2021.374
pii: acrep129622
pmc: PMC9037850
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2021374Informations de copyright
Copyright © 2022 The Author(s).
Déclaration de conflit d'intérêts
Conflict of interest: None
Références
J Urol. 1985 Feb;133(2):288-9
pubmed: 3968752
J Pak Med Assoc. 2008 Apr;58(4):209-11
pubmed: 18655434
J Clin Oncol. 2014 Jul 1;32(19):2001-9
pubmed: 24733792
J Ultrasound Med. 2006 Nov;25(11):1451-3
pubmed: 17060433
Arch Ital Urol Androl. 2010 Dec;82(4):287-90
pubmed: 21341584
Hum Pathol. 2020 Sep;103:25-33
pubmed: 32619438
J Urol. 1985 Jun;133(6):1062-4
pubmed: 3999214
Histopathology. 1993 Jul;23(1):89-91
pubmed: 7690009
Onco Targets Ther. 2016 Feb 09;9:655-69
pubmed: 26929638
Zhonghua Nan Ke Xue. 2015 Feb;21(2):157-60
pubmed: 25796691
Hum Pathol. 1995 Dec;26(12):1341-6
pubmed: 8522307
Mayo Clin Proc. 2021 Mar;96(3):828-829
pubmed: 33673939
Urology. 2018 Feb;112:172-175
pubmed: 29154985
Zhonghua Yi Xue Za Zhi (Taipei). 1990 Feb;45(2):139-42
pubmed: 2168252
Urology. 1980 Sep;16(3):305-6
pubmed: 7423716
J Pathol. 2006 Sep;210(1):32-41
pubmed: 16841375
Arch Pathol. 1971 May;91(5):456-70
pubmed: 5103954
J Submicrosc Cytol Pathol. 1994 Jul;26(3):387-93
pubmed: 8087801
Urol Int. 1994;53(4):222-4
pubmed: 7855941
J Ultrasound Med. 2008 Aug;27(8):1195-202
pubmed: 18645078
Int J Surg Case Rep. 2013;4(7):616-8
pubmed: 23708309
Cancer. 1976 Apr;37(4):1831-9
pubmed: 1260690
Arch Pathol Lab Med. 2010 Apr;134(4):630-3
pubmed: 20367315
Diagn Cytopathol. 2020 Feb;48(2):118-127
pubmed: 31697443
Am J Surg Pathol. 2005 Apr;29(4):520-3
pubmed: 15767808
AJR Am J Roentgenol. 2013 Jun;200(6):1215-25
pubmed: 23701056
Pathol Res Pract. 1986 May;181(2):260-4
pubmed: 3737482
J Urol. 1988 May;139(5):1062
pubmed: 3361646
Urology. 2018 Aug;118:189-191
pubmed: 29729363
Arch Pathol Lab Med. 1990 Jul;114(7):672-5
pubmed: 1694653
Cytopathology. 2014 Aug;25(4):279-81
pubmed: 23901807
Cancer. 1956 Mar-Apr;9(2):403-7
pubmed: 13304856
Cancer. 1964 Oct;17:1241-7
pubmed: 14236755
J Urol. 2005 Aug;174(2):723
pubmed: 16006963
Am J Surg Pathol. 2014 May;38(5):713-8
pubmed: 24441657
J Natl Cancer Inst. 2020 Dec 14;112(12):1242-1250
pubmed: 32107557
Acta Urol Belg. 1995 Mar;63(1):109-12
pubmed: 7725985
J Surg Case Rep. 2016 Nov 24;2016(11):
pubmed: 27887012
Caspian J Intern Med. 2021;12(Suppl 2):S388-S391
pubmed: 34760089
Histopathology. 2015 Jul;67(1):138-41
pubmed: 25406742
J Clin Ultrasound. 1991 Sep;19(7):442-5
pubmed: 1658073