A scoping review of small animal image-guided radiotherapy research: Advances, impact and future opportunities in translational radiobiology.
Preclinical models
Preclinical radiotherapy
Radiotherapy
Small animal irradiators
Journal
Clinical and translational radiation oncology
ISSN: 2405-6308
Titre abrégé: Clin Transl Radiat Oncol
Pays: Ireland
ID NLM: 101713416
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
25
03
2022
accepted:
04
04
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
To provide a scoping review of published studies using small animal irradiators and highlight the progress in preclinical radiotherapy (RT) studies enabled by these platforms since their development and commercialization in 2007. PubMed searches and manufacturer records were used to identify 907 studies that were screened with 359 small animal RT studies included in the analyses. These articles were classified as biology or physics contributions and into subgroups based on research aims, experimental models and other parameters to identify trends in the preclinical RT research landscape. From 2007 to 2021, most published articles were biology contributions (62%) whilst physics contributions accounted for 38% of the publications. The main research areas of physics articles were in dosimetry and calibration (24%), treatment planning and simulation (22%), and imaging (22%) and the studies predominantly used phantoms (41%) or This study captures the trends in preclinical RT research using small animal irradiators from 2007 to 2021. Our data show the increased uptake and outputs from preclinical RT studies in important areas of biology and physics research that could inform translation to clinical trials.
Sections du résumé
Background and purpose
UNASSIGNED
To provide a scoping review of published studies using small animal irradiators and highlight the progress in preclinical radiotherapy (RT) studies enabled by these platforms since their development and commercialization in 2007.
Materials and methods
UNASSIGNED
PubMed searches and manufacturer records were used to identify 907 studies that were screened with 359 small animal RT studies included in the analyses. These articles were classified as biology or physics contributions and into subgroups based on research aims, experimental models and other parameters to identify trends in the preclinical RT research landscape.
Results
UNASSIGNED
From 2007 to 2021, most published articles were biology contributions (62%) whilst physics contributions accounted for 38% of the publications. The main research areas of physics articles were in dosimetry and calibration (24%), treatment planning and simulation (22%), and imaging (22%) and the studies predominantly used phantoms (41%) or
Conclusions
UNASSIGNED
This study captures the trends in preclinical RT research using small animal irradiators from 2007 to 2021. Our data show the increased uptake and outputs from preclinical RT studies in important areas of biology and physics research that could inform translation to clinical trials.
Identifiants
pubmed: 35496817
doi: 10.1016/j.ctro.2022.04.004
pii: S2405-6308(22)00027-1
pmc: PMC9046563
doi:
Types de publication
Journal Article
Langues
eng
Pagination
112-119Subventions
Organisme : Medical Research Council
ID : MR/V009605/1
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/R001553/1
Pays : United Kingdom
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Phys Med Biol. 2019 Aug 14;64(16):165001
pubmed: 31252419
Sci Rep. 2019 Oct 4;9(1):14328
pubmed: 31586152
Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1591-9
pubmed: 18640502
Br J Radiol. 2017 Jan;90(1069):20160441
pubmed: 27612010
Radiother Oncol. 2017 Sep;124(3):482-487
pubmed: 28774597
Phys Med Biol. 2013 May 21;58(10):3377-95
pubmed: 23615380
Clin Cancer Res. 2013 Nov 15;19(22):6089-100
pubmed: 24043463
Oncoimmunology. 2021 Jan 31;10(1):1863631
pubmed: 33643689
Radiother Oncol. 2017 Sep;124(3):475-481
pubmed: 28697853
Sci Rep. 2021 May 27;11(1):11239
pubmed: 34045576
Clin Oncol (R Coll Radiol). 2015 Feb;27(2):70-6
pubmed: 25455408
J Mater Chem B. 2020 Mar 18;8(11):2216-2232
pubmed: 32100794
Br J Cancer. 2018 Nov;119(10):1200-1207
pubmed: 30318516
Nat Rev Cancer. 2014 Jul;14(7):481-93
pubmed: 24943811
Clin Oncol (R Coll Radiol). 2020 Jan;32(1):9-12
pubmed: 31543302
JAMA. 2006 Oct 11;296(14):1731-2
pubmed: 17032985
Nat Rev Cancer. 2017 Dec;17(12):751-765
pubmed: 29077691
Z Med Phys. 2014 Dec;24(4):323-34
pubmed: 24629309
Nat Rev Clin Oncol. 2016 Oct;13(10):627-42
pubmed: 27245279
Radiother Oncol. 2013 Dec;109(3):361-6
pubmed: 24183860
Clin Oncol (R Coll Radiol). 2019 May;31(5):272-282
pubmed: 30871751
Radiat Oncol. 2017 Nov 21;12(1):181
pubmed: 29157265
Cancers (Basel). 2019 Feb 01;11(2):
pubmed: 30717307
Br J Radiol. 2015 Jan;88(1045):20140634
pubmed: 25387486
Br J Radiol. 2017 Jan;90(1069):20160480
pubmed: 27683003
Phys Med. 2021 Aug;88:175-192
pubmed: 34284331
Med Phys. 2011 Jan;38(1):294-305
pubmed: 21361198
Radiat Oncol. 2019 Jul 31;14(1):134
pubmed: 31366364
Radiother Oncol. 2018 Mar;126(3):471-478
pubmed: 29269093
Nature. 2015 Apr 16;520(7547):373-7
pubmed: 25754329
Clin Transl Radiat Oncol. 2020 Sep 22;25:61-66
pubmed: 33072895
Z Med Phys. 2014 Dec;24(4):335-51
pubmed: 25125191
Radiother Oncol. 2016 Jan;118(1):43-51
pubmed: 26615717
Phys Med Biol. 2011 Jun 21;56(12):R55-83
pubmed: 21617291
J Thorac Oncol. 2021 Mar;16(3):e19-e20
pubmed: 33641724
Transl Oncol. 2012 Apr;5(2):77-84
pubmed: 22496923
J Res Natl Inst Stand Technol. 2013 Dec 30;118:403-18
pubmed: 26401441
Biostatistics. 2019 Apr 1;20(2):273-286
pubmed: 29394327
Cancers (Basel). 2020 May 18;12(5):
pubmed: 32443537
Radiother Oncol. 2021 Apr;157:155-162
pubmed: 33545252
Radiat Res. 2021 Mar 1;195(3):230-234
pubmed: 33347596
Phys Med Biol. 2019 Jun 21;64(12):12NT02
pubmed: 31082807
Phys Med Biol. 1993 Jan;38(1):71-92
pubmed: 8426870