A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
28 Apr 2022
28 Apr 2022
Historique:
received:
28
03
2022
accepted:
19
04
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies.
Identifiants
pubmed: 35497010
doi: 10.1039/d2ra01995g
pii: d2ra01995g
pmc: PMC9052952
doi:
Types de publication
Journal Article
Langues
eng
Pagination
13111-13115Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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