Development of a pH-sensitive functionalized metal organic framework:
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
08 Oct 2021
08 Oct 2021
Historique:
received:
14
06
2021
accepted:
09
10
2021
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Exploration of an efficient dual-drug based nanocarrier with high drug loading capacity, specific targeting properties, and long-term stability is highly desirable in cancer therapy. Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. To enhance the drug efficacy as well as to overcome the burst effect of drugs, here we synthesized a pH responsive folic acid (FA) and graphene oxide (GO) decorated zeolitical imidazolate frameworks-8 (GO-FA/ZIF-8), for targeted delivery of doxorubicin (DOX) and cyclophosphamide (CP), simultaneously. In this system, DOX molecules were encapsulated in the pores of ZIF-8 during
Identifiants
pubmed: 35497517
doi: 10.1039/d1ra04591a
pii: d1ra04591a
pmc: PMC9042314
doi:
Types de publication
Journal Article
Langues
eng
Pagination
33723-33733Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
Authors declare that they have no conflict of interest.
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