Recent advancements in synthetic methodologies of 3-substituted phthalides and their application in the total synthesis of biologically active natural products.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
24 Mar 2020
24 Mar 2020
Historique:
received:
22
01
2020
accepted:
06
03
2020
entrez:
2
5
2022
pubmed:
27
3
2020
medline:
27
3
2020
Statut:
epublish
Résumé
We have provided a critical review that focuses on key developments in the area of 3-substituted phthalides and their role in the development of important biologically active natural products. 3-Substituted phthalides are vital molecules owing to their fascinating biological activity. The scope, isolation, and characterization of various naturally occurring racemic and chiral 3-substituted phthalides have been covered. We have put significant emphasis on recently developed research methodologies for the synthesis of racemic and chiral 3-substituted phthalides. These newer approaches are essential for the development of newer and elegant strategies for the synthesis of phthalide-based or similar molecular architecture with broader substrate scope and higher stereoselectivities. Also, we have discussed the application of 3-substituted phthalides as a precursor for the synthesis of natural products and their analogs.
Identifiants
pubmed: 35497626
doi: 10.1039/d0ra00701c
pii: d0ra00701c
pmc: PMC9051324
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
12626-12652Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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