Maternal Urinary Cotinine Concentrations During Pregnancy Predict Infant BMI Trajectory After Birth: Analysis of 89617 Mother-Infant Pairs in the Japan Environment and Children's Study.
body mass index - BMI
cotinine concentrations
infant obesity
maternal smoking during pregnancy
second-hand smoking (SHS)
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
01
2022
accepted:
28
02
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
4
5
2022
Statut:
epublish
Résumé
Clinical or epidemiological conclusions remain undecided on the direct effects of active and second-hand smoking during pregnancy on childhood obesity. Urinary cotinine (UC) concentration, an accurate and quantitative marker for smoking, may elucidate the dose-dependent relationship between smoking during pregnancy and childhood obesity. To analyze the relationship between UC concentration and smoking questionnaire (SQ) classes for active and second-hand smoking in pregnant mothers and trajectory of infant Kaup index (body mass index: BMI). This multicenter prospective cohort study was conducted using a list-wise complete set of 35829 among 89617 mother-infant singleton pairs, recruited between 2011 and 2014, in the Japan Environment and Children's Study (JECS). Pairs were categorized according to UC levels (1 to 4 classes) or SQ (0 to 4 classes). Maternal BMI at delivery was the highest in UC class 4 (highest). Maternal and paternal education of ≥16 years and annual household income were lowest in UC class 4. Infant BMI was lower at birth, but trends in BMI and ΔBMI were higher from six to 36 months step-wise in the UC classes. The above tendency was observed in the list-wise complete dataset but was emphasized after multiple imputations and corrections of cofounders. UC concentration in five SQ classes largely fluctuated, and the relationship between SQ classes and trends in BMI and ΔBMI was not statistically significant. Infants from high UC mothers had a low BMI at birth, increasing from six to 36 months of age. UC concentrations, but not smoking questionnaire classes, predict infant BMI trajectory, suggesting that active and second-hand smoking affect child obesity in a dose-dependent manner.
Sections du résumé
Background
Clinical or epidemiological conclusions remain undecided on the direct effects of active and second-hand smoking during pregnancy on childhood obesity. Urinary cotinine (UC) concentration, an accurate and quantitative marker for smoking, may elucidate the dose-dependent relationship between smoking during pregnancy and childhood obesity. To analyze the relationship between UC concentration and smoking questionnaire (SQ) classes for active and second-hand smoking in pregnant mothers and trajectory of infant Kaup index (body mass index: BMI).
Methods
This multicenter prospective cohort study was conducted using a list-wise complete set of 35829 among 89617 mother-infant singleton pairs, recruited between 2011 and 2014, in the Japan Environment and Children's Study (JECS). Pairs were categorized according to UC levels (1 to 4 classes) or SQ (0 to 4 classes).
Results
Maternal BMI at delivery was the highest in UC class 4 (highest). Maternal and paternal education of ≥16 years and annual household income were lowest in UC class 4. Infant BMI was lower at birth, but trends in BMI and ΔBMI were higher from six to 36 months step-wise in the UC classes. The above tendency was observed in the list-wise complete dataset but was emphasized after multiple imputations and corrections of cofounders. UC concentration in five SQ classes largely fluctuated, and the relationship between SQ classes and trends in BMI and ΔBMI was not statistically significant.
Conclusion
Infants from high UC mothers had a low BMI at birth, increasing from six to 36 months of age. UC concentrations, but not smoking questionnaire classes, predict infant BMI trajectory, suggesting that active and second-hand smoking affect child obesity in a dose-dependent manner.
Identifiants
pubmed: 35498432
doi: 10.3389/fendo.2022.850784
pmc: PMC9049186
doi:
Substances chimiques
Cotinine
K5161X06LL
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
850784Informations de copyright
Copyright © 2022 Hirai, Okamoto, Masuzaki, Murata, Ogata, Sato, Horiuchi, Shinohara, Shinoki, Nishigori, Fujimori, Hosoya, Yasumura, Hashimoto, Yamagata, Shimabukuro and the JECS Group.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
BMJ Open. 2019 Feb 19;9(2):e023200
pubmed: 30782875
Int J Obes (Lond). 2019 Apr;43(4):652-662
pubmed: 30341407
Biol Psychiatry. 2019 Sep 1;86(5):344-355
pubmed: 31202491
Obes Rev. 2010 Oct;11(10):695-708
pubmed: 20331509
J Pediatr. 2013 Feb;162(2):415-20
pubmed: 23153864
J Acad Nutr Diet. 2020 Feb;120(2):288-318.e2
pubmed: 31547992
BMC Public Health. 2014 Jan 10;14:25
pubmed: 24410977
Cell Rep. 2018 Apr 3;23(1):68-77
pubmed: 29617674
Diabetologia. 2019 Oct;62(10):1773-1778
pubmed: 31451877
Nestle Nutr Inst Workshop Ser. 2015;81:87-97
pubmed: 26111566
BMC Pediatr. 2019 Mar 11;19(1):75
pubmed: 30857546
Nat Neurosci. 2012 Oct;15(10):1330-5
pubmed: 23007187
Clin Ter. 2019 May-Jun;170(3):e223-e230
pubmed: 31173054
Front Psychiatry. 2015 Sep 08;6:125
pubmed: 26441686
J Diabetes Investig. 2019 Jan;10(1):18-25
pubmed: 29978570
Int J Epidemiol. 2014 Oct;43(5):1593-606
pubmed: 25080528
J Acad Nutr Diet. 2014 Dec;114(12):1988-2000
pubmed: 25458748
Circulation. 2016 Oct 18;134(16):e336-e359
pubmed: 27619923
World Rev Nutr Diet. 2013;106:100-4
pubmed: 23428687
Int J Environ Res Public Health. 2019 May 13;16(9):
pubmed: 31086031
N Engl J Med. 2011 Nov 17;365(20):1876-85
pubmed: 22087679
Child Obes. 2016 Feb;12(1):1-11
pubmed: 26618249
J Endocrinol. 2017 Oct;235(1):R13-R31
pubmed: 28814527
Int J Environ Res Public Health. 2018 Nov 29;15(12):
pubmed: 30501044
Am J Clin Nutr. 2017 Mar;105(3):705-713
pubmed: 28179222
Int J Epidemiol. 2017 Apr 1;46(2):513-525
pubmed: 27649801
Int J Environ Res Public Health. 2020 Jul 31;17(15):
pubmed: 32751831
Pharmacol Biochem Behav. 1994 Feb;47(2):331-7
pubmed: 8146225
BMJ Open. 2013 Jan 24;3(1):
pubmed: 23355667
Int J Environ Res Public Health. 2020 Feb 19;17(4):
pubmed: 32092849
Trends Cardiovasc Med. 2020 Jan;30(1):39-45
pubmed: 30772134
Pediatr Res. 2019 Jun;85(7):961-966
pubmed: 30808020