Somatic Alteration Characteristics of Early-Onset Gastric Cancer.
Journal
Journal of oncology
ISSN: 1687-8450
Titre abrégé: J Oncol
Pays: Egypt
ID NLM: 101496537
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
10
2021
revised:
28
03
2022
accepted:
29
03
2022
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Gastric cancer is one of the most common and deadly cancer types worldwide, which brings millions of dollars of economic loss each year. Patients diagnosed with early-onset gastric cancer were reported to have a worse prognosis compared to other gastric cancer patients, while the mechanisms behind such phenomenon are unknown. To identify age-dependent somatic alternations in gastric cancer, next-generation sequencing targeting 425 genes was performed on 1688 gastric tumor tissues and corresponding plasma samples. In our study, the microsatellite instability (MSI) and chromosomal instability score (CIS) values increased along with the age of patients, which indicates that older patients display a less genomic stability pattern. The differences of somatic alternations between young and old groups were compared. Somatic mutations CDH1 and copy number gains of FGFR2 were identified to enrich in the younger gastric cancer patients, which may contribute to the worse prognosis of early-onset gastric cancer patients.
Identifiants
pubmed: 35498538
doi: 10.1155/2022/1498053
pmc: PMC9054482
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1498053Informations de copyright
Copyright © 2022 Qiyang Zhou et al.
Déclaration de conflit d'intérêts
HLC, HB, XW, and YS are employees of Nanjing Geneseeq Technology, Inc. All other authors declared no conflicts of interest.
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