Effects of tea polysaccharides in combination with polyphenols on dextran sodium sulfate-induced colitis in mice.
Colitis
Gut microbiota
Intestinal barrier
Tea polyphenols
Tea polysaccharides
Journal
Food chemistry: X
ISSN: 2590-1575
Titre abrégé: Food Chem X
Pays: Netherlands
ID NLM: 101751436
Informations de publication
Date de publication:
30 Mar 2022
30 Mar 2022
Historique:
received:
20
09
2021
revised:
05
12
2021
accepted:
19
12
2021
entrez:
2
5
2022
pubmed:
3
5
2022
medline:
3
5
2022
Statut:
epublish
Résumé
Both tea polysaccharides (TPS) and tea polyphenols (TPP) are promising in the treatment of inflammatory bowel disease (IBD). However, the effects of their combination against IBD are still unknown. In the present study, the therapeutic effects of TPS, TPP and TPS + TPP on dextran sodium sulfate-induced colitis in mice were investigated. Our results showed that administration of TPS + TPP achieved the best effects, followed by TPP and TPS, which were evidenced by the restoration of various physical signs (body weight, colon length and disease activity index) and the promoted intestinal barrier function (colon damage, mucin secretion and tight junction proteins expression). Furthermore, TPP and TPS decreased the relative abundance of Proteobacteria and Enterobacteriaceae, while TPP + TPS increased that of Lactobacillaceae and
Identifiants
pubmed: 35498966
doi: 10.1016/j.fochx.2021.100190
pii: S2590-1575(21)00078-X
pmc: PMC9039880
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100190Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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