Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva.

Female Humans Carcinoma, Squamous Cell / pathology DNA Hyperplasia / pathology Neoplasm Recurrence, Local / pathology Nicotinamide N-Methyltransferase / metabolism Vulva / pathology Vulvar Neoplasms / pathology
Nicotinamide N-methyltransferase squamous cell carcinoma vulvar cancer

Journal

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
ISSN: 1364-6893
Titre abrégé: J Obstet Gynaecol
Pays: England
ID NLM: 8309140

Informations de publication

Date de publication:
Aug 2022
Historique:
pubmed: 3 5 2022
medline: 30 9 2022
entrez: 2 5 2022
Statut: ppublish

Résumé

The molecular pathways involved in the development of vulvar squamous cell carcinoma (SCC) cancer are not completely known. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme associated with tumorigenesis and metastasis in a variety of cancers. Its role in vulvar cancer has not been studied, previously. Vulvar SCC, high and low grade squamous intraepithelial lesions (SILs) and benign squamous hyperplasia were analysed immunohistochemically. The mean staining score for vulvar SCC was significantly higher than the score for vulvar squamous hyperplasia (

Identifiants

DOI: 10.1080/01443615.2022.2049722 PMID: 35499473
pubmed: 35499473
doi: 10.1080/01443615.2022.2049722
doi:

Substances chimiques

DNA 9007-49-2
Nicotinamide N-Methyltransferase EC 2.1.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2325-2330

Auteurs

Zeliha Esin Çelik (ZE)

Department of Pathology, Selcuk University Hospital, Konya, Turkey.
ORCID: 0000-0002-3220-7845

Serra Akar (S)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Selcuk University Hospital, Selcuk University Medical School, Konya, Turkey.

Sıddıka Fındık (S)

Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Emine Aytekin (E)

Department of Obstetrics and Gynecology, Selcuk University Hospital, Selcuk University Medical School, Konya, Turkey.

Çetin Çelik (Ç)

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Selcuk University Hospital, Selcuk University Medical School, Konya, Turkey.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hyperplasie › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Nicotinamide N-methyltransferase › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Vulve › Nicotinamide N-methyltransferase expression in...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital féminin › Tumeurs de la vulve › Nicotinamide N-methyltransferase expression in...