Cholesterol-Mediated Seeding of Protein Corona on DNA Nanostructures for Targeted Delivery of Oligonucleotide Therapeutics to Treat Liver Fibrosis.
DNA tetrahedron
cholesterol conjugation
liver delivery
oligonucleotide therapeutics
protein corona
targeted delivery
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
24 05 2022
24 05 2022
Historique:
pubmed:
3
5
2022
medline:
15
11
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
The protein corona is a protein layer formed on the surface of nanoparticles administered in vivo and considerably affects the in vivo fate of nanoparticles. Although it is challenging to control protein adsorption on nanoparticles precisely, the protein corona may be harnessed to develop a targeted drug delivery system if the nanoparticles are decorated with a ligand with enhanced affinity to target tissue- and cell-homing proteins. Here, we prepared a DNA tetrahedron with trivalent cholesterol conjugation (Chol
Identifiants
pubmed: 35500062
doi: 10.1021/acsnano.1c08508
doi:
Substances chimiques
Protein Corona
0
Oligonucleotides
0
Ligands
0
Oligonucleotides, Antisense
0
Cholesterol
97C5T2UQ7J
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM