Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study.
Anxiety
Cognitive function
Common mental health problems
Cortisol
Depression
Longitudinal analysis
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
27
10
2021
revised:
29
03
2022
accepted:
06
04
2022
pubmed:
3
5
2022
medline:
18
6
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
Affective disorders are associated with accelerated cognitive ageing. However, current understanding of biological mechanisms which underlie these observed associations is limited. The aim of this study was to test: 1) Whether cortisol acts as a pathway in the association between depressive or anxiety symptoms across adulthood and midlife cognitive function; 2) Whether cortisol is associated with later depressive or anxiety symptoms, and cognitive function. Data were used from the National Child Development Study (NCDS), a sample of infants born in mainland UK during one week of 1958. A measure of the accumulation of affective symptoms was derived from data collected from age 23 to 42 using the Malaise Inventory Scale. Salivary cortisol measures were available at age 44-45. Cognitive function (memory, fluency, information processing) and affective symptoms were assessed at the age of 50. Path models were run to test whether salivary cortisol explained the longitudinal association between depressive or anxiety disorder symptoms and cognitive function. Direct effects of affective symptoms are shown across early to middle adulthood on cognitive function in midlife (memory and information processing errors). However, there were no effects of affective symptoms on cognitive function through cortisol measures. Additionally, cortisol measures were not significantly associated with subsequent affective symptoms or cognitive function at the age of 50. These results do not provide clear evidence to suggest that cortisol plays a role in the association between affective symptoms and cognitive function over this period of time. These findings contribute to our understanding of how the association between affective symptoms and cognitive function operates over time.
Identifiants
pubmed: 35500449
pii: S0022-3956(22)00210-2
doi: 10.1016/j.jpsychires.2022.04.007
pmc: PMC10442295
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-224Subventions
Organisme : Wellcome Trust
ID : 201292/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/3
Pays : United Kingdom
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
BMJ Open. 2017 Oct 12;7(10):e016085
pubmed: 29025828
Am J Psychiatry. 2003 Oct;160(10):1890-1
pubmed: 14514508
J Psychiatr Res. 2001 Mar-Apr;35(2):83-94
pubmed: 11377437
Dialogues Clin Neurosci. 2008;10(3):345-57
pubmed: 18979948
Braz J Med Biol Res. 2014 Feb;47(3):237-44
pubmed: 24652321
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
Soc Psychiatry Psychiatr Epidemiol. 1999 Jun;34(6):333-41
pubmed: 10422488
Br J Psychiatry. 2013 Mar;202(3):177-86
pubmed: 23457181
Nat Neurosci. 1998 May;1(1):69-73
pubmed: 10195112
Psychol Med. 2019 Feb;49(3):353-365
pubmed: 29792244
J Psychosom Res. 1986;30(2):147-52
pubmed: 3723445
Br J Psychiatry. 2019 Nov;215(5):675-682
pubmed: 30894229
J Neurosci. 2006 Aug 30;26(35):9047-56
pubmed: 16943563
Am J Geriatr Psychiatry. 2016 Oct;24(10):823-42
pubmed: 27591161
Br Med Bull. 1996 Jul;52(3):597-617
pubmed: 8949260
Brain Behav Immun. 2020 Feb;84:164-172
pubmed: 31785399
J Affect Disord. 2018 Dec 1;241:348-355
pubmed: 30144717
Front Aging Neurosci. 2019 Mar 01;11:43
pubmed: 30881301
Br J Psychiatry. 2021 May;218(5):254-260
pubmed: 32662372
Lancet Neurol. 2011 Sep;10(9):819-28
pubmed: 21775213
Ageing Res Rev. 2020 Dec;64:101171
pubmed: 32971258
BMJ Open. 2018 Apr 30;8(4):e019399
pubmed: 29712690
Psychoneuroendocrinology. 2013 Feb;38(2):300-5
pubmed: 22776419
Neurology. 2020 Jan 14;94(2):e133-e141
pubmed: 31831603
J Epidemiol Community Health. 2008 Mar;62(3):216-23
pubmed: 18272736
J Psychiatr Res. 2009 May;43(8):777-83
pubmed: 19054531