Cyanide resistant respiration and the alternative oxidase pathway: A journey from plants to mammals.
AOX
Cyanide resistant respiration
Mammals
Mitochondria
Plants
Thermogenicity
Journal
Biochimica et biophysica acta. Bioenergetics
ISSN: 1879-2650
Titre abrégé: Biochim Biophys Acta Bioenerg
Pays: Netherlands
ID NLM: 101731706
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
received:
14
12
2021
revised:
06
04
2022
accepted:
18
04
2022
pubmed:
3
5
2022
medline:
3
6
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
In a large number of organisms covering all phyla, the mitochondrial respiratory chain harbors, in addition to the conventional elements, auxiliary proteins that confer adaptive metabolic plasticity. The alternative oxidase (AOX) represents one of the most studied auxiliary proteins, initially identified in plants. In contrast to the standard respiratory chain, the AOX mediates a thermogenic cyanide-resistant respiration; a phenomenon that has been of great interest for over 2 centuries in that energy is not conserved when electrons flow through it. Here we summarize centuries of studies starting from the early observations of thermogenicity in plants and the identification of cyanide resistant respiration, to the fascinating discovery of the AOX and its current applications in animals under normal and pathological conditions.
Identifiants
pubmed: 35500614
pii: S0005-2728(22)00036-6
doi: 10.1016/j.bbabio.2022.148567
pii:
doi:
Substances chimiques
Cyanides
0
Mitochondrial Proteins
0
Plant Proteins
0
Oxidoreductases
EC 1.-
alternative oxidase
EC 1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
148567Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.