Profound Defect of Amphiregulin Secretion by Regulatory T Cells in the Gut of HIV-Treated Patients.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 05 2022
15 05 2022
Historique:
received:
21
07
2021
accepted:
07
03
2022
pubmed:
3
5
2022
medline:
20
5
2022
entrez:
2
5
2022
Statut:
ppublish
Résumé
The persistence of a leaky gut in HIV-treated patients leads to chronic inflammation with increased rates of cardiovascular, liver, kidney, and neurological diseases. Tissue regulatory T (tTreg) cells are involved in the maintenance of intestinal homeostasis and wound repair through the IL-33 pathway. In this study, we investigated whether the persistence of gut mucosal injury during HIV infection might be explained in part by a flaw in the mechanisms involved in tissue repair. We observed an increased level of IL-33 in the gut of HIV-infected patients, which is associated with an increased level of fibrosis and a low peripheral reconstitution of CD4
Identifiants
pubmed: 35500933
pii: jimmunol.2100725
doi: 10.4049/jimmunol.2100725
doi:
Substances chimiques
AREG protein, human
0
Amphiregulin
0
Interleukin-33
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2300-2308Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.